IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
EU - Europa 7.904
NA - Nord America 3.919
AS - Asia 3.581
SA - Sud America 578
Continente sconosciuto - Info sul continente non disponibili 249
AF - Africa 28
OC - Oceania 4
Totale 16.263
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Nazione #
RU - Federazione Russa 4.855
US - Stati Uniti d'America 3.848
SG - Singapore 1.087
CN - Cina 842
IE - Irlanda 765
IT - Italia 602
GB - Regno Unito 556
HK - Hong Kong 514
BR - Brasile 488
VN - Vietnam 378
UA - Ucraina 364
DE - Germania 308
IN - India 294
KR - Corea 156
TR - Turchia 156
FI - Finlandia 102
SE - Svezia 101
GR - Grecia 67
AR - Argentina 36
FR - Francia 35
NL - Olanda 34
CA - Canada 33
ES - Italia 30
JP - Giappone 30
MX - Messico 27
BD - Bangladesh 26
PK - Pakistan 25
AT - Austria 20
EC - Ecuador 18
ID - Indonesia 17
BE - Belgio 16
DK - Danimarca 13
PL - Polonia 11
IQ - Iraq 10
CO - Colombia 8
PY - Paraguay 8
ZA - Sudafrica 8
UZ - Uzbekistan 7
CL - Cile 6
VE - Venezuela 6
CH - Svizzera 5
ET - Etiopia 5
JM - Giamaica 5
AE - Emirati Arabi Uniti 4
DZ - Algeria 4
KZ - Kazakistan 4
LT - Lituania 4
TW - Taiwan 4
UY - Uruguay 4
AU - Australia 3
CR - Costa Rica 3
EG - Egitto 3
MN - Mongolia 3
NO - Norvegia 3
PE - Perù 3
RO - Romania 3
SA - Arabia Saudita 3
AM - Armenia 2
AO - Angola 2
BY - Bielorussia 2
IL - Israele 2
KE - Kenya 2
NP - Nepal 2
OM - Oman 2
PT - Portogallo 2
TN - Tunisia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BB - Barbados 1
BG - Bulgaria 1
BO - Bolivia 1
CZ - Repubblica Ceca 1
EU - Europa 1
GE - Georgia 1
GN - Guinea 1
HN - Honduras 1
HU - Ungheria 1
IR - Iran 1
JO - Giordania 1
KG - Kirghizistan 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MA - Marocco 1
MT - Malta 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PS - Palestinian Territory 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TT - Trinidad e Tobago 1
Totale 16.016
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Città #
Moscow 1.744
Dublin 765
Jacksonville 548
Hong Kong 514
Santa Clara 505
Singapore 405
Chandler 394
San Jose 363
Bengaluru 262
London 207
Ashburn 187
Hefei 173
Seoul 156
Chicago 134
Ho Chi Minh City 128
Princeton 120
Council Bluffs 117
Beijing 115
Medford 106
Bremen 103
Istanbul 102
Ann Arbor 85
The Dalles 84
Hanoi 80
Wilmington 65
San Mateo 63
Aversa 60
Roxbury 59
Boardman 53
Woodbridge 46
Munich 45
São Paulo 45
Naples 44
Caserta 42
Rome 38
Los Angeles 33
Dallas 29
Napoli 29
Milan 25
New York 25
Haiphong 22
Da Nang 21
Turku 21
Des Moines 20
Barcelona 19
Cambridge 16
Houston 16
Jinan 15
Brussels 13
Norwalk 13
Viterbo 13
Biên Hòa 12
Afragola 11
Belo Horizonte 11
Copenhagen 11
Lahore 11
Mountain View 11
Nanjing 11
Amsterdam 10
Montreal 10
Nuremberg 10
Vienna 10
Brasília 9
Columbus 9
Curitiba 9
Elora 9
Phoenix 9
Rio de Janeiro 9
Shanghai 9
Tokyo 9
Casal di Principe 8
Guayaquil 8
Marcianise 8
Mumbai 8
Piscataway 8
San Felice A Cancello 8
Volla 8
Atlanta 7
Cesano Maderno 7
Falkenstein 7
Falls Church 7
Frankfurt am Main 7
Guangzhou 7
Mexico City 7
Salvador 7
Santa Maria Capua Vetere 7
Shenyang 7
Tashkent 7
Thái Nguyên 7
Warsaw 7
Zhengzhou 7
Auburn Hills 6
Betim 6
Düsseldorf 6
Hangzhou 6
Memphis 6
Newark 6
Orem 6
Salt Lake City 6
Shenzhen 6
Totale 8.685
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Nome #
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 203
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 193
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 186
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 180
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 177
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 172
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells 169
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 169
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 163
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 162
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 161
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 158
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites 156
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 154
A balance between elongation and trimming regulates telomere stability in stem cells 154
Carbonic anhydrase activation profile of indole-based derivatives 153
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 152
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 152
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) 149
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 148
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 147
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 146
Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification 143
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 143
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 141
Discovery of N-Substituted-2-Oxoindolin Benzoylhydrazines as c-MET/SMO Modulators in EGFRi-Resistant Non-Small Cell Lung Cancer 140
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 140
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 140
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 140
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 139
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 136
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 136
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 134
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 134
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 134
From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment 133
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 133
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 130
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 130
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 129
Virtual screening with AutoDock: theory and practice 128
Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach 124
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 122
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 121
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 120
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 120
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 120
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 119
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 119
Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency 118
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 118
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain 117
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 117
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 117
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 116
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 116
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 115
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 115
The G-triplex DNA 114
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 113
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 113
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity 112
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 112
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 112
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 112
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 112
Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies 112
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 111
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 111
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 111
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 109
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 109
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 109
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 109
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 108
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 108
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 108
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 107
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 106
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 105
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 105
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 105
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 104
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 104
Sampling protein motion and solvent effect during ligand binding 104
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 104
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors 103
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 103
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 102
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 102
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 102
A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells 101
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 101
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 101
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 101
Identification of Dual Inhibitors Targeting Main Protease (Mpro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents 101
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations 100
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 99
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 99
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 99
Totale 12.664
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Categoria #
all - tutte 57.232
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.232
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022703 0 4 12 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024792 153 21 35 50 215 124 13 25 2 4 49 101
2024/20252.243 31 21 30 146 326 261 210 172 314 419 167 146
2025/20268.580 323 639 485 472 600 4.544 358 341 379 247 112 80
2026/2027301 81 220 0 0 0 0 0 0 0 0 0 0
Totale 16.263