IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
EU - Europa 7.863
NA - Nord America 3.698
AS - Asia 3.533
SA - Sud America 575
AF - Africa 28
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
Totale 15.703
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Nazione #
RU - Federazione Russa 4.855
US - Stati Uniti d'America 3.636
SG - Singapore 1.058
CN - Cina 828
IE - Irlanda 765
IT - Italia 572
GB - Regno Unito 556
HK - Hong Kong 511
BR - Brasile 487
VN - Vietnam 378
UA - Ucraina 362
DE - Germania 304
IN - India 294
TR - Turchia 156
KR - Corea 155
FI - Finlandia 102
SE - Svezia 101
GR - Grecia 67
AR - Argentina 35
FR - Francia 34
NL - Olanda 34
CA - Canada 29
JP - Giappone 29
ES - Italia 28
BD - Bangladesh 26
MX - Messico 25
PK - Pakistan 25
AT - Austria 20
EC - Ecuador 18
ID - Indonesia 17
BE - Belgio 16
DK - Danimarca 13
PL - Polonia 11
IQ - Iraq 10
CO - Colombia 8
PY - Paraguay 8
ZA - Sudafrica 8
UZ - Uzbekistan 7
CL - Cile 6
VE - Venezuela 6
CH - Svizzera 5
ET - Etiopia 5
AE - Emirati Arabi Uniti 4
DZ - Algeria 4
KZ - Kazakistan 4
LT - Lituania 4
TW - Taiwan 4
AU - Australia 3
EG - Egitto 3
JM - Giamaica 3
MN - Mongolia 3
NO - Norvegia 3
PE - Perù 3
RO - Romania 3
SA - Arabia Saudita 3
UY - Uruguay 3
AM - Armenia 2
AO - Angola 2
BY - Bielorussia 2
CR - Costa Rica 2
IL - Israele 2
KE - Kenya 2
NP - Nepal 2
OM - Oman 2
TN - Tunisia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AZ - Azerbaigian 1
BB - Barbados 1
BG - Bulgaria 1
BO - Bolivia 1
CZ - Repubblica Ceca 1
EU - Europa 1
GE - Georgia 1
GN - Guinea 1
HN - Honduras 1
HU - Ungheria 1
IR - Iran 1
JO - Giordania 1
KG - Kirghizistan 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MA - Marocco 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PS - Palestinian Territory 1
PT - Portogallo 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TT - Trinidad e Tobago 1
Totale 15.703
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Città #
Moscow 1.744
Dublin 765
Jacksonville 548
Hong Kong 511
Santa Clara 487
Singapore 400
Chandler 394
San Jose 362
Bengaluru 262
London 207
Hefei 173
Ashburn 156
Seoul 155
Chicago 132
Ho Chi Minh City 128
Princeton 119
Beijing 108
Medford 106
Bremen 103
Istanbul 102
Ann Arbor 85
The Dalles 84
Hanoi 80
Wilmington 65
San Mateo 63
Aversa 59
Roxbury 59
Boardman 53
Woodbridge 46
Munich 45
São Paulo 45
Caserta 42
Naples 41
Rome 38
Los Angeles 31
Dallas 29
Napoli 29
Milan 25
New York 24
Haiphong 22
Da Nang 21
Turku 21
Des Moines 20
Barcelona 19
Cambridge 16
Houston 16
Jinan 15
Brussels 13
Norwalk 13
Viterbo 13
Biên Hòa 12
Belo Horizonte 11
Copenhagen 11
Council Bluffs 11
Lahore 11
Mountain View 11
Nanjing 11
Amsterdam 10
Montreal 10
Nuremberg 10
Vienna 10
Brasília 9
Columbus 9
Curitiba 9
Elora 9
Rio de Janeiro 9
Casal di Principe 8
Guayaquil 8
Marcianise 8
Mumbai 8
Piscataway 8
San Felice A Cancello 8
Tokyo 8
Volla 8
Afragola 7
Cesano Maderno 7
Falkenstein 7
Falls Church 7
Guangzhou 7
Salvador 7
Santa Maria Capua Vetere 7
Shanghai 7
Shenyang 7
Tashkent 7
Thái Nguyên 7
Warsaw 7
Zhengzhou 7
Atlanta 6
Auburn Hills 6
Betim 6
Düsseldorf 6
Hangzhou 6
Mexico City 6
Orem 6
Shenzhen 6
Thái Bình 6
Tianjin 6
Wuhan 6
Addis Ababa 5
Asunción 5
Totale 8.488
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Nome #
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 200
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 192
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 183
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 176
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 173
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 166
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 164
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 161
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells 160
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 159
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 158
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 157
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites 153
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 153
Carbonic anhydrase activation profile of indole-based derivatives 152
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 151
A balance between elongation and trimming regulates telomere stability in stem cells 150
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 150
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) 147
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 146
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 146
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 145
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 141
Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification 140
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 139
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 139
Discovery of N-Substituted-2-Oxoindolin Benzoylhydrazines as c-MET/SMO Modulators in EGFRi-Resistant Non-Small Cell Lung Cancer 138
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 138
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 137
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 135
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 135
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 133
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 133
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 132
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 132
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 132
From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment 128
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 128
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 128
Virtual screening with AutoDock: theory and practice 127
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 126
Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach 122
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 122
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 119
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 119
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 119
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 119
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 118
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 117
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 116
Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency 115
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 115
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 115
The G-triplex DNA 114
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 114
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 114
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain 113
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 113
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 112
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 112
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 112
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 111
Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies 111
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 110
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 110
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 110
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 110
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 109
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 108
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity 107
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 107
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 107
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 107
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 107
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 106
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 106
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 106
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 105
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 105
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 104
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 104
Sampling protein motion and solvent effect during ligand binding 104
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 104
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 103
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 103
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors 102
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 102
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 101
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 101
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 101
A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells 100
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 100
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 100
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 100
Identification of Dual Inhibitors Targeting Main Protease (Mpro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents 100
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 99
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 99
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations 99
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 98
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 97
Totale 12.466
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Categoria #
all - tutte 54.188
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.188
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202125 0 0 0 0 0 0 0 0 0 0 0 25
2021/2022775 72 4 12 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024792 153 21 35 50 215 124 13 25 2 4 49 101
2024/20252.243 31 21 30 146 326 261 210 172 314 419 167 146
2025/20268.568 323 639 485 472 600 4.544 358 341 379 247 112 68
Totale 15.950