IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
EU - Europa 2.541
NA - Nord America 2.120
AS - Asia 344
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 5.013
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Nazione #
US - Stati Uniti d'America 2.111
IE - Irlanda 765
GB - Regno Unito 530
IT - Italia 358
UA - Ucraina 347
DE - Germania 240
CN - Cina 132
SG - Singapore 131
SE - Svezia 97
FI - Finlandia 80
GR - Grecia 65
TR - Turchia 47
PK - Pakistan 19
BE - Belgio 16
FR - Francia 16
CA - Canada 9
NL - Olanda 9
ES - Italia 6
IN - India 6
BR - Brasile 3
JP - Giappone 3
KR - Corea 3
RO - Romania 3
AT - Austria 2
AU - Australia 2
RU - Federazione Russa 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AM - Armenia 1
CH - Svizzera 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
EU - Europa 1
NO - Norvegia 1
PE - Perù 1
PL - Polonia 1
VN - Vietnam 1
Totale 5.013
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Città #
Dublin 765
Jacksonville 547
Chandler 394
London 203
Princeton 119
Medford 106
Bremen 103
Ann Arbor 85
Singapore 69
Wilmington 65
San Mateo 63
Roxbury 59
Boardman 52
Woodbridge 46
Caserta 38
Beijing 32
Napoli 29
Rome 29
Chicago 27
Des Moines 20
Milan 18
Ashburn 16
Cambridge 16
Brussels 13
Houston 13
Jinan 13
Norwalk 13
Naples 12
Lahore 11
Mountain View 11
Nanjing 11
Aversa 9
Elora 9
Los Angeles 9
New York 9
San Felice A Cancello 8
Cesano Maderno 7
Falls Church 7
Marcianise 7
Santa Maria Capua Vetere 7
Auburn Hills 6
Düsseldorf 6
Shenyang 6
Hebei 5
Munich 5
Zhengzhou 5
Bari 4
Boltiere 4
Fairfield 4
Florence 4
Groningen 4
Haikou 4
Nanchang 4
Ningbo 4
Redwood City 4
Salerno 4
Volla 4
Jiaxing 3
Leuven 3
Pelotas 3
Salt Lake City 3
Santa Maria Nuova 3
Scottsdale 3
Seoul 3
Trapani 3
Acerra 2
Acireale 2
Bologna 2
Caivano 2
Capua 2
Dearborn 2
Eboli 2
Hangzhou 2
Hanover 2
Melegnano 2
Olevano Sul Tusciano 2
San Giorgio La Molara 2
Seattle 2
St Petersburg 2
Taiyuan 2
Tianjin 2
Worcester 2
Wuhan 2
Acton 1
Afragola 1
Alcamo 1
Amsterdam 1
Andover 1
Baotou 1
Baranello 1
Barcelona 1
Benevento 1
Bhavnagar 1
Bisaccia 1
Capri 1
Chatsworth 1
Cogne 1
Delhi 1
Desio 1
Dubai 1
Totale 3.224
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Nome #
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 88
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 80
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 75
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 70
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 68
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 68
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 67
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 63
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 63
Virtual screening with AutoDock: theory and practice 62
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 61
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 61
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 59
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 59
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 59
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 58
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 58
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 55
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 54
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 53
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 53
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 53
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 53
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 52
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 52
A balance between elongation and trimming regulates telomere stability in stem cells 52
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 52
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 51
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 51
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 51
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 51
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 50
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 50
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 50
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 50
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 49
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 49
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 49
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 49
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 48
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 48
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 48
The G-triplex DNA 48
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 48
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 47
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 46
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 46
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 45
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 45
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 45
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 45
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations 44
Sampling protein motion and solvent effect during ligand binding 43
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 43
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 43
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 42
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 42
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism 41
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 40
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 40
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 40
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 40
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 40
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 40
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 40
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 40
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 39
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors 38
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 38
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 38
Identification of novel beta-secretase inhibitors through the inclusion of protein flexibility in virtual screening calculations 38
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 38
Identification of novel beta-secretase inhibitors through the inclusion of protein flexibility in virtual screening calculations 37
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 37
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 37
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 37
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 36
Novel N-2-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A(3) Receptor Antagonists: Inhibition of A(3)-Mediated Human Glioblastoma Cell Proliferation 36
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization 36
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 36
Conformational control of integrin-subtype selectivity in isodgr peptide motifs: A biological switch 35
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 35
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 35
Carbonic anhydrase activation profile of indole-based derivatives 35
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 34
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 34
PyRMD: A New Fully Automated AI-Powered Ligand-Based Virtual Screening Tool 34
The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: A successful drug discovery tale 33
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding 33
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 33
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 33
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 32
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 31
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation 31
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications 31
Phenylpyrazolo[1,5-a]quinazolin-5(4 H)-one: A suitable scaffold for the development of noncamptothecin topoisomerase i (Top1) inhibitors 30
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures? 30
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 30
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 30
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 29
Totale 4.594
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Categoria #
all - tutte 23.969
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.969
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020387 0 0 0 7 97 11 120 33 66 18 23 12
2020/2021809 75 0 90 59 131 3 121 79 20 112 94 25
2021/2022775 72 4 12 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024797 153 21 35 52 216 125 13 25 2 4 50 101
2024/202587 33 21 30 3 0 0 0 0 0 0 0 0
Totale 5.231