IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
NA - Nord America 2.610
EU - Europa 2.586
AS - Asia 531
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 5.736
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Nazione #
US - Stati Uniti d'America 2.601
IE - Irlanda 765
GB - Regno Unito 530
IT - Italia 392
UA - Ucraina 347
DE - Germania 243
SG - Singapore 190
CN - Cina 153
TR - Turchia 147
SE - Svezia 97
FI - Finlandia 81
GR - Grecia 65
PK - Pakistan 19
BE - Belgio 16
FR - Francia 16
NL - Olanda 11
CA - Canada 9
ES - Italia 8
IN - India 6
HK - Hong Kong 5
AT - Austria 4
BR - Brasile 3
JP - Giappone 3
KR - Corea 3
RO - Romania 3
AU - Australia 2
NO - Norvegia 2
PE - Perù 2
RU - Federazione Russa 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AM - Armenia 1
CH - Svizzera 1
CZ - Repubblica Ceca 1
DK - Danimarca 1
EU - Europa 1
PL - Polonia 1
TJ - Tagikistan 1
TW - Taiwan 1
VN - Vietnam 1
Totale 5.736
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Città #
Dublin 765
Jacksonville 547
Santa Clara 472
Chandler 394
London 203
Princeton 119
Singapore 115
Medford 106
Bremen 103
Istanbul 100
Ann Arbor 85
Wilmington 65
San Mateo 63
Roxbury 59
Boardman 52
Woodbridge 46
Caserta 41
Beijing 33
Rome 31
Napoli 29
Chicago 27
Aversa 23
Des Moines 20
Milan 19
Ashburn 17
Cambridge 16
Jinan 14
Naples 14
Brussels 13
Houston 13
Norwalk 13
Lahore 11
Mountain View 11
Nanjing 11
New York 10
Elora 9
Los Angeles 9
San Felice A Cancello 8
Cesano Maderno 7
Falls Church 7
Marcianise 7
Munich 7
Santa Maria Capua Vetere 7
Auburn Hills 6
Düsseldorf 6
Shenyang 6
Hebei 5
Hong Kong 5
Piscataway 5
Shanghai 5
Zhengzhou 5
Bari 4
Boltiere 4
Fairfield 4
Florence 4
Groningen 4
Haikou 4
Nanchang 4
Ningbo 4
Redwood City 4
Salerno 4
Volla 4
Jiaxing 3
Leuven 3
Pelotas 3
Salt Lake City 3
Santa Maria Nuova 3
Scottsdale 3
Seoul 3
Trapani 3
Acerra 2
Acireale 2
Bologna 2
Caivano 2
Capua 2
Casavatore 2
Dearborn 2
Eboli 2
Hangzhou 2
Hanover 2
Helsinki 2
Melegnano 2
Olevano Sul Tusciano 2
San Giorgio La Molara 2
Seattle 2
St Petersburg 2
Taiyuan 2
Tianjin 2
Vienna 2
Worcester 2
Wuhan 2
Acton 1
Afragola 1
Alcamo 1
Amsterdam 1
Andover 1
Baotou 1
Baranello 1
Barcelona 1
Benevento 1
Totale 3.883
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Nome #
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 93
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 88
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 79
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 77
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 77
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 76
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 73
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 69
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 69
Virtual screening with AutoDock: theory and practice 69
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 67
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 66
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 64
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 64
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 64
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 64
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 63
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 61
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 60
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 60
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 60
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 60
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 58
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 58
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 58
A balance between elongation and trimming regulates telomere stability in stem cells 58
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 57
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 57
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 57
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 57
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 57
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 56
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 56
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 56
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 55
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 55
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 55
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 55
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 55
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 54
The G-triplex DNA 54
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 54
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 53
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 53
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 52
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 51
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 51
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 51
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 51
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 50
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 50
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 49
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 49
Sampling protein motion and solvent effect during ligand binding 48
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations 48
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 47
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 47
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism 46
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 46
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 46
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 46
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 45
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 45
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 45
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 45
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 45
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 44
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 44
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 44
New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors 43
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 43
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 43
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 43
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 42
Novel N-2-Substituted Pyrazolo[3,4-d]pyrimidine Adenosine A(3) Receptor Antagonists: Inhibition of A(3)-Mediated Human Glioblastoma Cell Proliferation 42
Identification of novel beta-secretase inhibitors through the inclusion of protein flexibility in virtual screening calculations 42
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 42
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 42
Carbonic anhydrase activation profile of indole-based derivatives 42
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 41
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization 41
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding 41
Identification of novel beta-secretase inhibitors through the inclusion of protein flexibility in virtual screening calculations 41
Protein Flexibility in Virtual Screening: The BACE-1 Case Study 40
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 40
Conformational control of integrin-subtype selectivity in isodgr peptide motifs: A biological switch 39
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 39
PyRMD: A New Fully Automated AI-Powered Ligand-Based Virtual Screening Tool 39
The first sphingosine 1-phosphate lyase inhibitors against multiple sclerosis: A successful drug discovery tale 38
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 38
Lead Discovery of Dual G-Quadruplex Stabilizers and Poly(ADP-ribose) Polymerases (PARPs) Inhibitors: A New Avenue in Anticancer Treatment 38
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 38
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 36
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 36
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 35
Phenylpyrazolo[1,5-a]quinazolin-5(4 H)-one: A suitable scaffold for the development of noncamptothecin topoisomerase i (Top1) inhibitors 35
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation 35
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications 35
Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures? 35
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 35
Totale 5.155
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Categoria #
all - tutte 27.199
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.199
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020283 0 0 0 0 0 11 120 33 66 18 23 12
2020/2021809 75 0 90 59 131 3 121 79 20 112 94 25
2021/2022775 72 4 12 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024797 153 21 35 52 216 125 13 25 2 4 50 101
2024/2025817 33 21 30 147 327 259 0 0 0 0 0 0
Totale 5.961