IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
EU - Europa 8.197
NA - Nord America 4.879
AS - Asia 3.610
SA - Sud America 585
Continente sconosciuto - Info sul continente non disponibili 249
AF - Africa 29
OC - Oceania 4
Totale 17.553
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Nazione #
RU - Federazione Russa 4.855
US - Stati Uniti d'America 4.766
SG - Singapore 1.105
IT - Italia 858
CN - Cina 842
IE - Irlanda 767
GB - Regno Unito 578
HK - Hong Kong 515
BR - Brasile 493
VN - Vietnam 379
UA - Ucraina 364
DE - Germania 310
IN - India 296
KR - Corea 156
TR - Turchia 156
FI - Finlandia 102
SE - Svezia 101
GR - Grecia 67
CA - Canada 51
FR - Francia 37
AR - Argentina 36
NL - Olanda 35
JP - Giappone 34
ES - Italia 30
MX - Messico 27
BD - Bangladesh 26
PK - Pakistan 25
AT - Austria 20
ID - Indonesia 19
EC - Ecuador 18
BE - Belgio 16
DK - Danimarca 14
PL - Polonia 12
IQ - Iraq 10
CO - Colombia 9
CR - Costa Rica 8
PY - Paraguay 8
ZA - Sudafrica 8
HN - Honduras 7
UZ - Uzbekistan 7
VE - Venezuela 7
CL - Cile 6
JM - Giamaica 6
RO - Romania 6
BB - Barbados 5
CH - Svizzera 5
ET - Etiopia 5
AE - Emirati Arabi Uniti 4
DZ - Algeria 4
KZ - Kazakistan 4
LT - Lituania 4
TW - Taiwan 4
UY - Uruguay 4
AU - Australia 3
EE - Estonia 3
EG - Egitto 3
MN - Mongolia 3
NO - Norvegia 3
PE - Perù 3
SA - Arabia Saudita 3
AM - Armenia 2
AO - Angola 2
BY - Bielorussia 2
GT - Guatemala 2
IL - Israele 2
KE - Kenya 2
NI - Nicaragua 2
NP - Nepal 2
OM - Oman 2
PH - Filippine 2
PT - Portogallo 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AW - Aruba 1
AZ - Azerbaigian 1
BG - Bulgaria 1
BO - Bolivia 1
BS - Bahamas 1
CZ - Repubblica Ceca 1
EU - Europa 1
GE - Georgia 1
GN - Guinea 1
HU - Ungheria 1
IR - Iran 1
JO - Giordania 1
KG - Kirghizistan 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MA - Marocco 1
MQ - Martinica 1
MT - Malta 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PS - Palestinian Territory 1
SC - Seychelles 1
SY - Repubblica araba siriana 1
Totale 17.305
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Città #
Moscow 1.744
Dublin 765
Jacksonville 549
Santa Clara 538
Hong Kong 514
San Jose 478
Singapore 408
Chandler 394
Ashburn 368
Council Bluffs 292
Bengaluru 262
London 207
Hefei 173
Seoul 156
Chicago 142
Ho Chi Minh City 128
Princeton 126
Beijing 115
Medford 107
Bremen 103
Milan 103
Istanbul 102
Ann Arbor 85
The Dalles 84
Hanoi 81
Wilmington 65
San Mateo 63
Aversa 60
Roxbury 59
Naples 54
Boardman 53
Rome 48
Woodbridge 46
Munich 45
São Paulo 45
Caserta 42
Los Angeles 38
Dallas 36
New York 35
Miano 29
Napoli 29
Haiphong 22
Da Nang 21
Turku 21
Des Moines 20
Barcelona 19
Houston 18
Cambridge 16
Jinan 15
Brussels 13
Norwalk 13
Tokyo 13
Viterbo 13
Afragola 12
Atlanta 12
Biên Hòa 12
Belo Horizonte 11
Copenhagen 11
Lahore 11
Montreal 11
Mountain View 11
Nanjing 11
Phoenix 11
Amsterdam 10
Brasília 10
Nuremberg 10
Piscataway 10
Vienna 10
Bologna 9
Brooklyn 9
Columbus 9
Curitiba 9
Elora 9
Rio de Janeiro 9
Shanghai 9
Casal di Principe 8
Frankfurt am Main 8
Guayaquil 8
Marcianise 8
Mumbai 8
Newark 8
Salvador 8
San Felice A Cancello 8
Volla 8
Warsaw 8
Bari 7
Boston 7
Buffalo 7
Cesano Maderno 7
Falkenstein 7
Falls Church 7
Guangzhou 7
Mexico City 7
Orem 7
Salt Lake City 7
Santa Maria Capua Vetere 7
Shenyang 7
Tashkent 7
Thái Nguyên 7
Zhengzhou 7
Totale 9.386
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Nome #
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 213
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 201
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 194
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 190
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 187
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells 182
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 182
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 182
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 173
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites 170
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 168
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 168
A balance between elongation and trimming regulates telomere stability in stem cells 165
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 165
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 162
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 161
Carbonic anhydrase activation profile of indole-based derivatives 161
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 159
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) 158
Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification 156
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 156
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 154
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 152
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 151
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 150
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 148
Discovery of N-Substituted-2-Oxoindolin Benzoylhydrazines as c-MET/SMO Modulators in EGFRi-Resistant Non-Small Cell Lung Cancer 147
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 147
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 147
From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment 146
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 146
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 146
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 146
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 144
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 143
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 142
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 141
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 139
Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach 138
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 137
Virtual screening with AutoDock: theory and practice 136
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 135
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 130
Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency 129
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 129
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 129
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 128
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 128
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 127
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 127
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 127
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 126
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 126
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain 124
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 124
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 124
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 124
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 123
The G-triplex DNA 123
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 123
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 122
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity 121
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 121
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 121
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 121
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 120
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 120
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 119
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 119
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 117
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 117
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 117
Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies 117
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 117
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 115
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 115
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 114
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 114
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 114
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 113
Sampling protein motion and solvent effect during ligand binding 112
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 112
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 112
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 112
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 111
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 111
Identification of Dual Inhibitors Targeting Main Protease (Mpro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents 111
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 110
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 110
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 110
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 110
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 110
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors 109
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 108
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 108
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 108
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism 107
A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells 106
Conformational control of integrin-subtype selectivity in isodgr peptide motifs: A biological switch 106
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 106
Totale 13.502
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Categoria #
all - tutte 60.914
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.914
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022687 0 0 0 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024792 153 21 35 50 215 124 13 25 2 4 49 101
2024/20252.243 31 21 30 146 326 261 210 172 314 419 167 146
2025/20268.580 323 639 485 472 600 4.544 358 341 379 247 112 80
2026/20271.591 81 256 643 611 0 0 0 0 0 0 0 0
Totale 17.553