IRIS
COSCONATI, Sandro
 Distribuzione geografica
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Continente #
EU - Europa 7.597
AS - Asia 3.058
NA - Nord America 2.955
SA - Sud America 546
AF - Africa 21
OC - Oceania 3
Continente sconosciuto - Info sul continente non disponibili 2
Totale 14.182
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Nazione #
RU - Federazione Russa 4.737
US - Stati Uniti d'America 2.913
SG - Singapore 956
IE - Irlanda 765
CN - Cina 725
GB - Regno Unito 545
IT - Italia 501
HK - Hong Kong 473
BR - Brasile 468
UA - Ucraina 360
DE - Germania 296
IN - India 284
VN - Vietnam 172
KR - Corea 155
TR - Turchia 155
FI - Finlandia 102
SE - Svezia 101
GR - Grecia 66
AR - Argentina 34
JP - Giappone 28
FR - Francia 25
PK - Pakistan 25
BD - Bangladesh 23
NL - Olanda 23
MX - Messico 20
AT - Austria 17
CA - Canada 17
EC - Ecuador 17
BE - Belgio 16
ID - Indonesia 15
DK - Danimarca 12
IQ - Iraq 10
ES - Italia 9
PL - Polonia 7
PY - Paraguay 7
UZ - Uzbekistan 7
CO - Colombia 6
ZA - Sudafrica 6
CL - Cile 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
DZ - Algeria 3
NO - Norvegia 3
RO - Romania 3
TW - Taiwan 3
UY - Uruguay 3
VE - Venezuela 3
AM - Armenia 2
AO - Angola 2
AU - Australia 2
BY - Bielorussia 2
CH - Svizzera 2
EG - Egitto 2
IL - Israele 2
JM - Giamaica 2
KE - Kenya 2
KZ - Kazakistan 2
LT - Lituania 2
MN - Mongolia 2
NP - Nepal 2
PE - Perù 2
SA - Arabia Saudita 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AZ - Azerbaigian 1
BB - Barbados 1
BO - Bolivia 1
CZ - Repubblica Ceca 1
EU - Europa 1
GE - Georgia 1
HN - Honduras 1
IR - Iran 1
JO - Giordania 1
KG - Kirghizistan 1
KW - Kuwait 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MA - Marocco 1
NZ - Nuova Zelanda 1
PS - Palestinian Territory 1
PT - Portogallo 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
Totale 14.182
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Città #
Moscow 1.670
Dublin 765
Jacksonville 547
Santa Clara 475
Hong Kong 473
Chandler 394
Singapore 332
Bengaluru 262
London 206
Hefei 173
Seoul 155
Princeton 119
Medford 106
Bremen 103
Istanbul 102
Ann Arbor 85
The Dalles 84
Beijing 75
Ashburn 74
Wilmington 65
Ho Chi Minh City 63
San Mateo 63
Roxbury 59
Boardman 53
Aversa 52
Woodbridge 46
Munich 44
São Paulo 42
Caserta 41
Hanoi 34
Rome 31
Chicago 30
Napoli 29
Naples 27
Dallas 26
Los Angeles 25
Turku 21
Des Moines 20
Milan 20
Cambridge 16
Houston 16
Jinan 15
Brussels 13
Norwalk 13
Viterbo 13
Belo Horizonte 11
Haiphong 11
Lahore 11
Mountain View 11
Nanjing 11
New York 11
Copenhagen 10
Brasília 9
Curitiba 9
Elora 9
Rio de Janeiro 9
Biên Hòa 8
Columbus 8
Marcianise 8
Nuremberg 8
San Felice A Cancello 8
Vienna 8
Volla 8
Afragola 7
Amsterdam 7
Cesano Maderno 7
Falkenstein 7
Falls Church 7
Guangzhou 7
Guayaquil 7
Santa Maria Capua Vetere 7
Shanghai 7
Shenyang 7
Tashkent 7
Tokyo 7
Zhengzhou 7
Auburn Hills 6
Betim 6
Düsseldorf 6
Hangzhou 6
Salvador 6
Shenzhen 6
Thái Nguyên 6
Tianjin 6
Wuhan 6
Boston 5
Goiânia 5
Guarulhos 5
Haikou 5
Hebei 5
Jakarta 5
Jiaxing 5
Montreal 5
Mumbai 5
Ningbo 5
Piscataway 5
Quito 5
Stockholm 5
Warsaw 5
Addis Ababa 4
Totale 7.464
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Nome #
Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers 181
Antitumor efficacy of Kisspeptin in human malignant mesothelioma cells 173
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists 168
Best Matching Protein Conformations and Docking Programs for a Virtual Screening Campaign Against SMO Receptor 161
Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer 157
Synthesis and gene silencing properties of siRNAs containing terminal amide linkages 149
Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity 147
Switchable Protecting Strategy for Solid Phase Synthesis of DNA and RNA Interacting Nucleopeptides 147
Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication 147
Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence 145
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies 144
Dual MET and SMO Negative Modulators Overcome Resistance to EGFR Inhibitors in Human Nonsmall Cell Lung Cancer 144
Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase 143
A balance between elongation and trimming regulates telomere stability in stem cells 140
Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells 138
A unique capsular polysaccharide structure from the psychrophilic marine bacterium Colwellia psychrerythraea 34H that mimics antifreeze (glyco)proteins 137
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites 136
Inhibition of Ocular Aldose Reductase by a New Benzofuroxane Derivative Ameliorates Rat Endotoxic Uveitis 135
Carbonic anhydrase activation profile of indole-based derivatives 135
A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity 133
Disulfide Bond Replacement with 1,4- and 1,5-Disubstituted [1,2,3]-Triazole on C-X-C Chemokine Receptor Type 4 (CXCR4) Peptide Ligands: Small Changes that Make Big Differences 132
Antiproliferative and proapoptotic activity of CLM3, a novel multiple tyrosine kinase inhibitor, alone and in combination with SN-38 on endothelial and cancer cells 129
3-Aryl-[1,2,4]triazino[4,3-a ]benzimidazol-4(10 H)-one: A novel template for the design of highly selective A2B adenosine receptor antagonists 128
Lead Optimization of 2-Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitors for the Treatment of Gliomas 125
4-Imidazo[2,1-b]thiazole-1,4-DHPs and neuroprotection: preliminary study in hits searching 125
A novel smaller β-defensin-derived peptide is active against multidrug-resistant bacterial strains 125
Properly Substituted Analogues of BIX-01294 Lose Inhibition of G9a Histone Methyltransferase and Gain Selective Anti-DNA Methyltransferase 3A Activity 124
Architecture of the human urotensin II receptor: Comparison of the binding domains of peptide and non-peptide urotensin II agonists 124
Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis 123
Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS) 123
A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies 123
N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase 122
Water-soluble pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as human A 3 adenosine receptor antagonists 122
Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification 121
4-Substituted Benzenesulfonamides Incorporating Bi/Tricyclic Moieties Act as Potent and Isoform-Selective Carbonic Anhydrase II/IX Inhibitors 121
Discovery of N-Substituted-2-Oxoindolin Benzoylhydrazines as c-MET/SMO Modulators in EGFRi-Resistant Non-Small Cell Lung Cancer 120
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening 120
tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells 119
3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)- one, a novel adenosine receptor antagonist with A2A-mediated neuroprotective effects 115
Virtual screening with AutoDock: theory and practice 114
Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach 113
Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: Model construction and docking calculations 113
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity 112
From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment 110
Shading the TRF2 Recruiting Function: A New Horizon in Drug Development 110
Shooting for selective druglike G-quadruplex binders: Evidence for telomeric DNA damage and tumor cell death 110
The G-triplex DNA 110
Synthesis, in Vitro, and in Cell Studies of a New Series of [Indoline-3,2 '-thiazolidine]-Based p53 Modulators 109
Design, Synthesis, and Biological Evaluation of Novel 2-((2-4-(Substituted)phenylpiperazin-1-yl)ethyl)amino)-5 '-N-ethylcarboxamidoadenosines as Potent and Selective Agonists of the A(2A) Adenosine Receptor 107
Structure-Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors 107
Revisiting a Receptor-Based Pharmacophore Hypothesis for Human A(2A) Adenosine Receptor Antagonists 107
Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach 106
State-of-the-Art Methodologies for the Discovery and Characterization of DNA G-Quadruplex Binders 106
Residence Time, a New parameter to Predict Neurosteroidogenic Efficacy of Translocator Protein (TSPO) Ligands: the Case Study of N,N-Dialkyl-2-arylindol-3-ylglyoxylamides 106
New 2-Heterocyclyl-imidazo[2,1-i]purin-5-one Derivatives as Potent and Selective Human A(3) Adenosine Receptor Antagonists 105
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition 105
New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors 104
Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes 104
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain 103
Human recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library 103
Structure-activity relationship of the exopolysaccharide from a psychrophilic bacterium: A strategy for cryoprotection 103
Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies 103
Structural and Conformational Requisites in DNA Quadruplex Groove Binding: Another Piece to the Puzzle 102
Structure-Based Virtual Screening and Biological Evaluation of Mycobacterium tuberculosis Adenosine 5 '-Phosphosulfate Reductase Inhibitors 102
SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage 102
Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d[pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2 101
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense 101
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75 99
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by diketo acid derivatives 98
Progresses in the pursuit of aldose reductase inhibitors: The structure-based lead optimization step 98
Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status 98
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H 98
Unbinding of Translocator Protein 18 kDa (TSPO) Ligands: From in Vitro Residence Time to in Vivo Efficacy via in Silico Simulations 98
Quinolinonyl Non-Diketo Acid Derivatives as Inhibitors of HIV-1 Ribonuclease H and Polymerase Functions of Reverse Transcriptase 98
Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders 97
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2-aryloxyalkanoic acids: A docking and molecular dynamics study 97
Exploring the chemical space of G-quadruplex binders: Discovery of a novel chemotype targeting the human telomeric sequence 96
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 96
Sampling protein motion and solvent effect during ligand binding 96
Imidazo[2,1-b]thiazole system: A scaffold endowing dihydropyridines with selective cardiodepressant activity 96
Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations 95
Monothiocarbamates Strongly Inhibit Carbonic Anhydrases in Vitro and Possess Intraocular Pressure Lowering Activity in an Animal Model of Glaucoma 95
Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments 95
Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency 94
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors 94
Synthesis and biological evaluation of novel peptidomimetics as rhodesain inhibitors 94
Decoration of Chondroitin Polysaccharide with Threonine: Synthesis, Conformational Study, and Ice-Recrystallization Inhibition Activity 94
Identification of anxiolytic/nonsedative agents among indol-3- ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor 93
Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity 92
Synthesis and Biological Evaluation of CTP Synthetase Inhibitors as Potential Agents for the Treatment of African Trypanosomiasis 92
Synthesis and biological evaluation of 4-phenylquinazoline-2-carboxamides designed as a novel class of potent ligands of the translocator protein 92
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 92
Ensemble-docking approach on BACE-1: Pharmacophore perception and guidelines for drug design 92
Identification of 5-arylidene-4-thiazolidinone derivatives endowed with dual activity as aldose reductase inhibitors and antioxidant agents for the treatment of diabetic complications 92
Pursuing aldose reductase inhibitors through in situ cross-docking and similarity-based virtual screening 92
Development of novel 1,4-benzodiazepine-based Michael acceptors as antitrypanosomal agents 92
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism 91
Everolimus induces Met inactivation by disrupting the FKBP12/Met complex 91
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase 91
A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAFV600E in cancer cells 90
Totale 11.397
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Categoria #
all - tutte 48.357
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.357
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021454 0 0 0 0 0 3 121 79 20 112 94 25
2021/2022775 72 4 12 24 262 9 12 25 34 89 49 183
2022/20231.567 147 14 25 139 211 133 7 93 716 16 32 34
2023/2024792 153 21 35 50 215 124 13 25 2 4 49 101
2024/20252.243 31 21 30 146 326 261 210 172 314 419 167 146
2025/20267.035 323 639 485 472 600 4.516 0 0 0 0 0 0
Totale 14.417