Triplex with a twist: Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The G-triplex DNA
COSCONATI, Sandro;
2013
Abstract
Triplex with a twist: Through metadynamics calculations, the thrombin binding aptamer (TBA) has been shown to adopt a stable G-triplex structural motif, in addition to the usual G-quadruplex (see scheme). An 11-mer oligonucleotide was also shown to form a stable G-triplex, whose structural and thermodynamic properties have been characterized. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.File in questo prodotto:
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