"Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence and better serum resistance. The-oretical data allowed to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ."
Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ. © 2012 American Chemical Society.
Tuning RNA Interference by Enhancing siRNA/PAZ Recognition
POTENZA, Nicoletta;Mosca N;RUSSO, Aniello;COSCONATI, Sandro
;MESSERE, Anna
2013
Abstract
Chemically modified siRNAs were synthesized to enhance the corresponding silencing activities. The introduced modifications endowed siRNAs with high silencing effect, long RNAi persistence, and better serum resistance. Theoretical data allowed us to correlate the observed siRNAs interfering performance with the peculiar interactions with PAZ. © 2012 American Chemical Society.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
