Chemopreventive effect of a milk whey by-product derived from Buffalo (Bubalus bubalis) in protecting from colorectal carcinogenesis

Background: Several studies show that natural foods are a source of compounds with anticancer properties that affect the gut microbiota and its metabolites. In the present study, we investigate the effect of a delactosed buffalo milk whey by-product (DMW) on colorectal carcinogenesis. Methods: The effect of DMW on colorectal carcinoma (CRC) was investigated in the established mouse model of azoxymethane (AOM)-induced colon carcinoma, which closely resembles the human clinical condition of CRC...

Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

There has been an intense focus to uncover the molecular mechanisms by which fasting triggers the adaptive cellular responses in the major organs of the body. Here, we show that in mice, hepatic S-adenosylmethionine (SAMe)—the principal methyl donor—acts as a metabolic sensor of nutrition to fine-tune the catabolic-fasting response by modulating phosphatidylethanolamine N-methyltransferase (PEMT) activity, endoplasmic reticulum-mitochondria contacts, β-oxidation, and ATP production in the liv...

Modelling the growth of a PHB producer methanotrophic bacterial strain using a Computational Fluid Dynamic approach: Discontinuous methane feeding strategy

Replacing fossil plastic with green and biobased alternatives is one of the most significant challenges of this century. Polyhydroxyalkanoates, more specifically, poly(3-hydroxybutyrate) (PHB), have been found as a very promising alternative to traditional plastics, but currently, they are about 2% of the bioplastics produced. In this work, the growth of a methanotrophic strain belonging to the Methylocystis species, a natural producer of poly(3-hydroxybutyrate), was modelled in a bubble colu...

Cherubino Gambardella.Piccolo Album antologico di sei collage