Choline is a quaternary ammonium base that represents an essential component of phospholipids and cell membranes. Malignant transformation is associated with an abnormal choline metabolism at a higher levels with respect to those exclusively due to cell multiplication. The use of Positron Emission Tomography/Computed Tomography (PET/CT) with radiocholine (RCH), labeled with 11 C or 18 F, is widely diffuse in oncology, with main reference to restaging of patients with prostate cancer. In this paper we have analyzed the most important issues related to the possible utilization of RCH in diagnostic imaging of human cancer.
Biochemical and Pathophysiological Premises to Positron Emission Tomography With Choline Radiotracers.
CUCCURULLO, Vincenzo
Conceptualization
;CASTORIA, GabriellaMethodology
;MANSI, LuigiValidation
2017
Abstract
Choline is a quaternary ammonium base that represents an essential component of phospholipids and cell membranes. Malignant transformation is associated with an abnormal choline metabolism at a higher levels with respect to those exclusively due to cell multiplication. The use of Positron Emission Tomography/Computed Tomography (PET/CT) with radiocholine (RCH), labeled with 11 C or 18 F, is widely diffuse in oncology, with main reference to restaging of patients with prostate cancer. In this paper we have analyzed the most important issues related to the possible utilization of RCH in diagnostic imaging of human cancer.File in questo prodotto:
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