A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins αvβ3 and αvβ5 (see scheme). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Increasing αvβ3 selectivity of the anti-angiogenic drug cilengitide by N-methylation
COSCONATI, Sandro;
2011
Abstract
A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins αvβ3 and αvβ5 (see scheme). © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.File in questo prodotto:
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