Three genotypes were identified: PER3(5/5) (n = 8), PER3(4/5) (n = 42) and PER3(4/4) (n = 24). The three genotypes showed equivalent increases in sleepiness across the night as measured by KSS. A significant mood increase (F = 1.66, P = 0.034) following SD was found in subjects with higher level of neuroticism compared to subjects with intermediate and low level of neuroticism. A high percentage (87%) of the group with high neuroticism was of PER 4/4 subjects. Conclusion: No difference in subjective sleepiness following SD was found between PER 5/5 and PER 4/4 subjects. Our result of mood activation in the high neuroticism group suggests that PER3 polymorphism can also contribute to different response patterns to SD which involve mood and personality dimensions.

BEHAVIORAL CHANGES FOLLOWING TOTAL SLEEP DEPRIVATION. THE ROLE OF PER3 POLYMORPHISM AND OF PERSONALITY FACTORS

BARBATO, Giuseppe;CERRATO, Flavia
2010

Abstract

Three genotypes were identified: PER3(5/5) (n = 8), PER3(4/5) (n = 42) and PER3(4/4) (n = 24). The three genotypes showed equivalent increases in sleepiness across the night as measured by KSS. A significant mood increase (F = 1.66, P = 0.034) following SD was found in subjects with higher level of neuroticism compared to subjects with intermediate and low level of neuroticism. A high percentage (87%) of the group with high neuroticism was of PER 4/4 subjects. Conclusion: No difference in subjective sleepiness following SD was found between PER 5/5 and PER 4/4 subjects. Our result of mood activation in the high neuroticism group suggests that PER3 polymorphism can also contribute to different response patterns to SD which involve mood and personality dimensions.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/219218
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