Three genotypes were identified: PER3(5/5) (n = 8), PER3(4/5) (n = 42) and PER3(4/4) (n = 24). The three genotypes showed equivalent increases in sleepiness across the night as measured by KSS. A significant mood increase (F = 1.66, P = 0.034) following SD was found in subjects with higher level of neuroticism compared to subjects with intermediate and low level of neuroticism. A high percentage (87%) of the group with high neuroticism was of PER 4/4 subjects. Conclusion: No difference in subjective sleepiness following SD was found between PER 5/5 and PER 4/4 subjects. Our result of mood activation in the high neuroticism group suggests that PER3 polymorphism can also contribute to different response patterns to SD which involve mood and personality dimensions.
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