Endoscope-assisted trans-oral approach (EATA) to remove a rare pleomorphic adenoma of the nasopharynx

BACKGROUND: Pleomorphic adenomas are benign tumors that typically arise from the salivary glands, most commonly the parotid gland. However, they can also occur in minor salivary glands and ectopic salivary tissue, and in very rare cases, these tumors arise in the nasopharynx. CASE REPORT: We present a rare case of a pleomorphic adenoma originating from the nasopharynx in a 49-year-old female patient. The patient was affected by snoring, bilateral nasal obstruction, and bilateral otitis media with effusion. Radiological investigations identified a well-defined mass in the nasopharynx. The tumor was successfully removed via a transoral approach, and histopathological examination confirmed the diagnosis of pleomorphic adenoma. CONCLUSION: This case highlights the importance of considering pleomorphic adenoma in the differential diagnosis of nasopharyngeal masses, even though rarely occurs in this location. Complete surgical excision with preservation of the tumor capsule is crucial to prevent recurrence.