Pregnancy outcome in proteinuria-onset and hypertension-onset preeclampsia

Objective: To evaluate pregnancy outcome in preeclampsia (PE), according to the timing of onset of proteinuria and hypertension. Methods: Preeclamptic women were retrospectively divided into proteinuria-onset and hypertension-onset PE according to the first symptom. Maternal and perinatal outcome were assessed in both the groups. Results: One hundred and ninety five single pregnancies complicated by PE were included. According to the first symptom, they were divided into two groups: proteinuria-onset PE (n = 49, 25.1%) and hypertension-onset PE (n = 146, 74.9%). Pregnancy and neonatal outcome was significantly worse in proteinuria-onset PE. Conclusion: Proteinuria-onset PE is associated with an increased risk of adverse pregnancy outcome than hypertension-onset PE.