Combining TSH measurement with TIRADS assessment to further improve the detection of thyroid cancers

Background: Thyroid imaging reporting and data Systems (TiradSs) have demonstrated high performance in risk stratification of thyroid nodules (TNs). However, further improvements are needed in view of the ongoing project of an international TiradS. even if thyroid-stimulating hormone (TSH) measurement is traditionally used to assess the thyroid function, several papers have reported that higher TSH levels are associated with the presence of differentiated thyroid carcinoma (dTc). The present study aimed to investigate the role of TSH levels as improvement factor of american college of radiology (acr-), european Thyroid association (eU-), and Korean Society (K-)TiradS. MeTHodS: Patients undergoing thyroidectomy were reviewed and TNs were re-assessed according to TiradSs. different TSH subgroups were attained. Histology was the reference standard. dTc risk of relapse was assessed according to american Thyroid association guidelines. reSUlTS: The study series included 97 patients with 39.2% cancer prevalence. acr-, eU-, and K-TiradS indicated fine-needle aspiration cytology (FNAC) in 78.9%, 81.6%, and 92.1% of cases, respectively. All high-risk DTC had FNAC indication according to the three TIRADSs. The cancer rate was significantly lower in patients with TSH<0.4 mIU/L (P=0.04). The receiver operating characteristic (ROC) curve analysis showed that the best TSH cut-off to detect DTC patient was >1.3 mIU/L with Area Under the Curve (AUC)=0.70. Combining TSH data with TIRADS, the sensitivity of ACR-, EU-, and K-TIRADS increased to 92.1% 89.5%, and 94.7%, respectively. Conversely, the rate of unnecessary FNac raised. at multivariate analysis, gender, TSH, and TiradS were independent predictors of cancer. coNclUSioNS: even if TiradSs are strongly reliable to stratify the risk of malignancy of TNs, measuring TSH can further improve our sensitivity in detecting dTc