Cancer is a complex illness marked by aberrant cellular behaviors and genetic variances, resulting in tumor heterogeneity that presents challenges in cancer prognosis and treatment. This review underscores the significance of comprehending tumor heterogeneity, offering perspectives on its attributes and the intricacies involved in its quantification. By emphasizing the need for effective therapies targeting tumor heterogeneity, this work contributes to raising awareness about this elusive characteristic of cancer.Cancer manifests as a multifaceted disease, characterized by aberrant cellular proliferation, survival, migration, and invasion. Tumors exhibit variances across diverse dimensions, encompassing genetic, epigenetic, and transcriptional realms. This heterogeneity poses significant challenges in prognosis and treatment, affording tumors advantages through an increased propensity to accumulate mutations linked to immune system evasion and drug resistance. In this review, we offer insights into tumor heterogeneity as a crucial characteristic of cancer, exploring the difficulties associated with measuring and quantifying such heterogeneity from clinical and biological perspectives. By emphasizing the critical nature of understanding tumor heterogeneity, this work contributes to raising awareness about the importance of developing effective cancer therapies that target this distinct and elusive trait of cancer.
From Chaos to Opportunity: Decoding Cancer Heterogeneity for Enhanced Treatment Strategies
Ianniello M.;Sirica R.;Cascella M.;Caraglia M.;
2023
Abstract
Cancer is a complex illness marked by aberrant cellular behaviors and genetic variances, resulting in tumor heterogeneity that presents challenges in cancer prognosis and treatment. This review underscores the significance of comprehending tumor heterogeneity, offering perspectives on its attributes and the intricacies involved in its quantification. By emphasizing the need for effective therapies targeting tumor heterogeneity, this work contributes to raising awareness about this elusive characteristic of cancer.Cancer manifests as a multifaceted disease, characterized by aberrant cellular proliferation, survival, migration, and invasion. Tumors exhibit variances across diverse dimensions, encompassing genetic, epigenetic, and transcriptional realms. This heterogeneity poses significant challenges in prognosis and treatment, affording tumors advantages through an increased propensity to accumulate mutations linked to immune system evasion and drug resistance. In this review, we offer insights into tumor heterogeneity as a crucial characteristic of cancer, exploring the difficulties associated with measuring and quantifying such heterogeneity from clinical and biological perspectives. By emphasizing the critical nature of understanding tumor heterogeneity, this work contributes to raising awareness about the importance of developing effective cancer therapies that target this distinct and elusive trait of cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
