The esterification reaction of different amino acidswith methanol catalyzed by H2SO4 was first studied in the smallvolume of thin films generated by ESI microdroplet deposition.The reaction is promoted by the pneumatic spray of the ESI sourceand reaches its maximum efficiency at a thin film temperature of 70°C. Selective esterification of the COOH moiety was demon-strated. Microdroplet size and thin film volume and lifetime arecritical parameters that influenced the reaction outcome. Asexpected, L-tyrosine and L-phenylalanine having aromatic side chainsubstituents were the most reactive amino acids, reaching absolute yields of around 40−50%. The amino acid esterification catalyzedby H2SO4 in a thin film occurs under synthetic conditions in which the same reaction in the bulk is not observed
Sulfuric Acid Catalyzed Esterification of Amino Acids in Thin Film
Andreina RicciConceptualization
;
2023
Abstract
The esterification reaction of different amino acidswith methanol catalyzed by H2SO4 was first studied in the smallvolume of thin films generated by ESI microdroplet deposition.The reaction is promoted by the pneumatic spray of the ESI sourceand reaches its maximum efficiency at a thin film temperature of 70°C. Selective esterification of the COOH moiety was demon-strated. Microdroplet size and thin film volume and lifetime arecritical parameters that influenced the reaction outcome. Asexpected, L-tyrosine and L-phenylalanine having aromatic side chainsubstituents were the most reactive amino acids, reaching absolute yields of around 40−50%. The amino acid esterification catalyzedby H2SO4 in a thin film occurs under synthetic conditions in which the same reaction in the bulk is not observedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
