Abstract: Background: Cardiovascular disease is a global health concern and reducing plasma LDL-Clevels is a major goal in cardiovascular prevention. Our study aimed to evaluate the effectiveness of anutraceutical formulation including leucoselect® phytosome®, red yeast rice, policosanol and folicacid on LDL-c levels in patients at low cardiovascular risk with dyslipidemia. Materials and Methods:We prospectively enrolled all consecutive patients with dyslipidemia at low cardiovascular riskwho were unresponsive to diet and physical activity. Clinical assessments and laboratory analyses,encompassing lipid profile, hepatic function, and CPK levels, were performed at baseline priorto initiating treatment and repeated at the 12-week mark following administration of the studynutraceutical. Results: Sixty (60) consecutive patients (mean age 48.02 ± 10.1 years; 60% male) wereincluded. At the 12-week follow-up, a statistically significant reduction in Total Cholesterol (13.1%)and LDL-c serum level (20.4%) was observed. Hepatic and muscular function remain stable overthe time. The adherence to therapy was 99% and the persistence was maximum. Conclusions: Thenutraceutical formulation including leucoselect® phytosome® red yeast rice, policosanol and folicacid significantly reduced the LDL-c plasma levels, consistent with previous research showing thatthe bioactive component in red yeast rice—lovastatin—is effective in addressing problems with lipidmetabolism. Importantly, it was safe and well-tolerated among patients with dyslipidemia in areal-world setting. (9) (PDF) The Lipid-Lowering Efficacy of a Nutraceutical Combination Including Leucoselect Phytosome, Red Yeast Rice, Policosanol and Folic Acid in Dyslipidaemia Patients: Real-World Insights. Available from: https://www.researchgate.net/publication/379455055_The_Lipid-Lowering_Efficacy_of_a_Nutraceutical_Combination_Including_Leucoselect_Phytosome_Red_Yeast_Rice_Policosanol_and_Folic_Acid_in_Dyslipidaemia_Patients_Real-World_Insights [accessed Apr 04 2024].
The Lipid-Lowering Efficacy of a Nutraceutical Combination Including Leucoselect Phytosome, Red Yeast Rice, Policosanol and Folic Acid in Dyslipidaemia Patients: Real-World Insights
Russo, Vincenzo;Napolitano, Nicola;Ascrizzi, Antonia;Sasso, Ferdinando Carlo;Caturano, Alfredo;Mauriello, Alfredo
2024
Abstract
Abstract: Background: Cardiovascular disease is a global health concern and reducing plasma LDL-Clevels is a major goal in cardiovascular prevention. Our study aimed to evaluate the effectiveness of anutraceutical formulation including leucoselect® phytosome®, red yeast rice, policosanol and folicacid on LDL-c levels in patients at low cardiovascular risk with dyslipidemia. Materials and Methods:We prospectively enrolled all consecutive patients with dyslipidemia at low cardiovascular riskwho were unresponsive to diet and physical activity. Clinical assessments and laboratory analyses,encompassing lipid profile, hepatic function, and CPK levels, were performed at baseline priorto initiating treatment and repeated at the 12-week mark following administration of the studynutraceutical. Results: Sixty (60) consecutive patients (mean age 48.02 ± 10.1 years; 60% male) wereincluded. At the 12-week follow-up, a statistically significant reduction in Total Cholesterol (13.1%)and LDL-c serum level (20.4%) was observed. Hepatic and muscular function remain stable overthe time. The adherence to therapy was 99% and the persistence was maximum. Conclusions: Thenutraceutical formulation including leucoselect® phytosome® red yeast rice, policosanol and folicacid significantly reduced the LDL-c plasma levels, consistent with previous research showing thatthe bioactive component in red yeast rice—lovastatin—is effective in addressing problems with lipidmetabolism. Importantly, it was safe and well-tolerated among patients with dyslipidemia in areal-world setting. (9) (PDF) The Lipid-Lowering Efficacy of a Nutraceutical Combination Including Leucoselect Phytosome, Red Yeast Rice, Policosanol and Folic Acid in Dyslipidaemia Patients: Real-World Insights. Available from: https://www.researchgate.net/publication/379455055_The_Lipid-Lowering_Efficacy_of_a_Nutraceutical_Combination_Including_Leucoselect_Phytosome_Red_Yeast_Rice_Policosanol_and_Folic_Acid_in_Dyslipidaemia_Patients_Real-World_Insights [accessed Apr 04 2024].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
