Clinical features of patients with home isolation SARS-COV-2 infection: A multicenter retrospective study in southern Italy

Pisaturo M.; De Angelis G.; Maggi P.; Sangiovanni V.; Numis F. G.; Gentile I.; Masullo A.; Rescigno C.; Calabria G.; Megna A. S.; Gambardella M.; Manzillo E.; Giolitto G.; Rossomando A.; Buonomo A. R.; Macera M.; Messina V.; Pagano A.; Pisapia R.; Farella N.; Bosso G.; Coppola N.; Coppola N.; Monari C.; Sagnelli C.; Maggi P.; Sangiovanni V.; Numis F. G.; Gentile I.; Masullo A.; Rescigno C.; Calabria G.; Megna A. S.; Gambardella M.; Manzillo E.; Russo G.; Esposito V.; Messina V.; Pisaturo M.; Allegorico E.; Biagio Pinchera; Pisapia R.; Catalano M.; Salzillo A.; Porta G.; Buonomo A. R.; Scotto R.; Pinchera B.; Zappulo E.; Viceconte G.; Moriello N. S.; Foggia M.; Macera M.; Calo F.; Rossomando A. M.; Russo A.; Farella N.; Liorre G.; Paradiso L.; Liberti A.; Bosso G.; Serra C.; Vicario F. D.; Minerva V.; Selva V.; Simeone F.; De Angelis G.; De Pascalis S.; Pontillo V.

doi:10.3390/life11040347

To describe epidemiological and clinical features of patients confirmed as having SARSCoV-2 infection and managed in isolation at home. We performed a multicenter retrospective study enrolling all SARS-CoV-2-positive adults evaluated from 28 February to 31 May 2020 at one of nine COVID-19 Units in southern Italy: we included patients receiving care at home and those admitted to hospital. We defined patients with not-severe disease if they were asymptomatic or experienced a mild infection that did not need oxygen (O2 ) therapy and those with a severe infection if hospitalized and required O2 therapy. We enrolled 415 patients with SARS-CoV-2 infection: 77 were managed in isolation at home, 338 required hospital management. The 77 patients in home isolation were less frequently male than hospitalized patients (55% vs. 64%; <0.01) and were younger (median age 45 years (IQR:19) vs. 62 (IQR 22); p < 0.01), had a lower Charlson comorbidity index (median 0 (IQR2) vs. 6 (IQR 3); p < 0.01), and included fewer subjects with an underlying chronic disease (36% vs. 59%; p < 0.01). According to a binomial logistic regression analysis, a younger age (OR: 0.96 (95% IC: 0.94–0.98), p < 0.01) and a low Charlson comorbidity index (OR: 0.66 (95% IC: 0.54–0.83); p < 0.01) were independent factors associated with at-home management. The identification of subjects with SARS-CoV-2 infection who could be managed in home isolation is useful in clinical practice. A younger age and no comorbidities were identified as factors independently associated with home management.

Clinical features of patients with home isolation SARS-COV-2 infection: A multicenter retrospective study in southern Italy

Pisaturo M.;De Angelis G.;Maggi P.;Sangiovanni V.;Numis F. G.;Gentile I.;Masullo A.;Rescigno C.;Calabria G.;Megna A. S.;Gambardella M.;Manzillo E.;Giolitto G.;Rossomando A.;Buonomo A. R.;Macera M.;Messina V.;Pagano A.;Pisapia R.;Farella N.;Bosso G.;Coppola N.;Coppola N.;Monari C.;Sagnelli C.;Maggi P.;Sangiovanni V.;Numis F. G.;Gentile I.;Masullo A.;Rescigno C.;Calabria G.;Megna A. S.;Gambardella M.;Manzillo E.;Russo G.;Esposito V.;Messina V.;Pisaturo M.;Allegorico E.;Biagio Pinchera;Pisapia R.;Catalano M.;Salzillo A.;Porta G.;Buonomo A. R.;Scotto R.;Pinchera B.;Zappulo E.;Viceconte G.;Moriello N. S.;Foggia M.;Macera M.;Calo F.;Rossomando A. M.;Russo A.;Farella N.;Liorre G.;Paradiso L.;Liberti A.;Bosso G.;Serra C.;Vicario F. D.;Minerva V.;Selva V.;Simeone F.;De Angelis G.;De Pascalis S.;Pontillo V.

2021

Abstract

To describe epidemiological and clinical features of patients confirmed as having SARSCoV-2 infection and managed in isolation at home. We performed a multicenter retrospective study enrolling all SARS-CoV-2-positive adults evaluated from 28 February to 31 May 2020 at one of nine COVID-19 Units in southern Italy: we included patients receiving care at home and those admitted to hospital. We defined patients with not-severe disease if they were asymptomatic or experienced a mild infection that did not need oxygen (O2 ) therapy and those with a severe infection if hospitalized and required O2 therapy. We enrolled 415 patients with SARS-CoV-2 infection: 77 were managed in isolation at home, 338 required hospital management. The 77 patients in home isolation were less frequently male than hospitalized patients (55% vs. 64%; <0.01) and were younger (median age 45 years (IQR:19) vs. 62 (IQR 22); p < 0.01), had a lower Charlson comorbidity index (median 0 (IQR2) vs. 6 (IQR 3); p < 0.01), and included fewer subjects with an underlying chronic disease (36% vs. 59%; p < 0.01). According to a binomial logistic regression analysis, a younger age (OR: 0.96 (95% IC: 0.94–0.98), p < 0.01) and a low Charlson comorbidity index (OR: 0.66 (95% IC: 0.54–0.83); p < 0.01) were independent factors associated with at-home management. The identification of subjects with SARS-CoV-2 infection who could be managed in home isolation is useful in clinical practice. A younger age and no comorbidities were identified as factors independently associated with home management.