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IRIS
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings.
Thrombotic and hemorrhagic complications of COVID-19 in adults hospitalized in high-income countries compared with those in adults hospitalized in low- and middle-income countries in an international registry
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S.;Salvator H.;Sanchez O.;Sanchez E.;Sanchez-Miralles A.;Sancho-Shimizu V.;Sandhu G.;Sandhu Z.;Sandrine P. -F.;Sandulescu O.;Santos M.;Sarfo-Mensah S.;Sarmento Banheiro B.;Sarmiento I. C. E.;Sarton B.;Satyapriya S.;Satyawati R.;Saviciute E.;Savvidou P.;Saw Y. T.;Schaffer J.;Schermer T.;Scherpereel A.;Schneider M.;Schroll S.;Schwameis M.;Scicluna B.;Scott J. T.;Scott-Brown J.;Sedillot N.;Seitz T.;Selvarajoo M.;Semaille C.;Semple M. G.;Senian R. B.;Senneville E.;Sepulveda C.;Sequeira F.;Sequeira T.;Neto A. S.;Balazote P. S.;Shadowitz E.;Shahidan S. A.;Shamsah M.;Sharjeel S.;Sharma P.;Shaw C. A.;Shaw V.;Sheenan J. R.;Shi H.;Shime N.;Shimizu K.;Shrapnel S.;Shum H. P.;Mohammed N. S.;Siang N. Y.;Sibiude J.;Siddiqui A.;Sigfrid L.;Sillaots P.;Silva C.;Silva R.;Silva M. J.;Lim Heng B. S.;Sin W. C.;Singh P.;Singh B. C.;Sitompul P. A.;Sivam K.;Skogen V.;Smith S.;Smood B.;Smyth C.;Smyth M.;Snacken M.;So D.;Soh T. V.;Solomon J.;Solomon T.;Somers E.;Sommet A.;Song R.;Song M. J.;Song T.;Chia J. 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S.;Tierney P.;Tieroshyn V.;Timsit J. -F.;Tissot N.;Toal F.;Yang Toh J. Z.;Toki M.;Tonby K.;Tonnii S. L.;Torre M.;Torres M.;Torres A.;Torres-Zevallos H.;Towers M.;Trapani T.;Trioux T.;Tromeur C.;Trontzas I.;Trouillon T.;Truong J.;Tual C.;Tubiana S.;Tuite H.;Turgeon A. F.;Turmel J. -M.;Turtle L. C. W.;Tveita A.;Twardowski P.;Uchiyama M.;Udy A.;Ullrich R.;Uribe A.;Usman A.;Uyeki T. M.;Vajdovics C.;Val-Flores L.;Valran A.;Van de Velde S.;van den Berge M.;Van der Feltz M.;van der Palen J.;van der Valk P.;Van Der Vekens N.;Van der Voort P.;Van Der Werf S.;van Gulik L.;Van Hattem J.;van Netten C.;van Someren Greve F.;van Veen I.;Van Willigen H.;Vanel N.;Vanoverschelde H.;Varghese P.;Varrone M.;Vasudayan S. R.;Vauchy C.;Veeran S.;Veislinger A.;Vencken S.;Ventura S.;Verbon A.;Vidal J. E.;Vieira C.;Villanueva J. A.;Villar J.;Villeneuve P. -M.;Villoldo A.;Visseaux B.;Visser H.;Vitiello C.;Vonkeman H.;Vuotto F.;Wahab N. H.;Wahab S. A.;Wahid N. A.;Wainstein M.;Walsh L.;Wang C. -H.;Webb S.;Wei J.;Weil K.;Wen T. P.;Wesselius S.;Wham M.;Whelan B.;White N.;Wicky P. H.;Wiedemann A.;Wijaya S. O.;Wille K.;Willems S.;Williams B.;Williams V.;Williams P. J.;Wils E. -J.;Wittman J.;Wong C.;Wong X. C.;Wong Y. S.;Wong T. F.;Xian G. E.;Xian L. S.;Kuan P. X.;Xynogalas I.;Binti Mohd Yakop S. R.;Yamazaki M.;Yarad E.;Yazdanpanah Y.;Liang Hing N. Y.;Yelnik C.;Yeoh C. H.;Yerkovich S.;Yokoyama T.;Yonis H.;Yousif O.;Zaaqoq A.;Zabbe M.;Zacharowski K.;Zahid M.;Zahran M.;Binti Zaidan N. Z.;Zambon M.;Zambrano M.;Zanella A.;Zaynah N.;Zayyad H.;Zoufaly A.;Zucman D.
2023
Abstract
Background: COVID-19 has been associated with a broad range of thromboembolic, ischemic, and hemorrhagic complications (coagulopathy complications). Most studies have focused on patients with severe disease from high-income countries (HICs). Objectives: The main aims were to compare the frequency of coagulopathy complications in developing countries (low- and middle-income countries [LMICs]) with those in HICs, delineate the frequency across a range of treatment levels, and determine associations with in-hospital mortality. Methods: Adult patients enrolled in an observational, multinational registry, the International Severe Acute Respiratory and Emerging Infections COVID-19 study, between January 1, 2020, and September 15, 2021, met inclusion criteria, including admission to a hospital for laboratory-confirmed, acute COVID-19 and data on complications and survival. The advanced-treatment cohort received care, such as admission to the intensive care unit, mechanical ventilation, or inotropes or vasopressors; the basic-treatment cohort did not receive any of these interventions. Results: The study population included 495,682 patients from 52 countries, with 63% from LMICs and 85% in the basic treatment cohort. The frequency of coagulopathy complications was higher in HICs (0.76%-3.4%) than in LMICs (0.09%-1.22%). Complications were more frequent in the advanced-treatment cohort than in the basic-treatment cohort. Coagulopathy complications were associated with increased in-hospital mortality (odds ratio, 1.58; 95% CI, 1.52-1.64). The increased mortality associated with these complications was higher in LMICs (58.5%) than in HICs (35.4%). After controlling for coagulopathy complications, treatment intensity, and multiple other factors, the mortality was higher among patients in LMICs than among patients in HICs (odds ratio, 1.45; 95% CI, 1.39-1.51). Conclusion: In a large, international registry of patients hospitalized for COVID-19, coagulopathy complications were more frequent in HICs than in LMICs (developing countries). Increased mortality associated with coagulopathy complications was of a greater magnitude among patients in LMICs. Additional research is needed regarding timely diagnosis of and intervention for coagulation derangements associated with COVID-19, particularly for limited-resource settings.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/514631
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
