To the Editor: Golino et al. (Feb. 24 issue)1 showed that serotonin is released into the coronary circulation during angioplasty and that this vasoactive substance may contribute to the occurrence of vasoconstriction distal to the dilated site. Furthermore, the authors showed that the distal vasoconstriction is attenuated by intravenous ketanserin, a serotonin2-receptor antagonist. We have recently examined2,3 the effects of the intracoronary infusion of 1 mg of ketanserin on proximal and distal coronary arterial segments in 12 patients immediately after percutaneous transluminal coronary angioplasty (PTCA), in both vessels subjected to PTCA and control vessels. After PTCA, marked. © 1994, Massachusetts Medical Society. All rights reserved.
Intracoronary ketanserin after coronary angioplasty
Golino P.
1994
Abstract
To the Editor: Golino et al. (Feb. 24 issue)1 showed that serotonin is released into the coronary circulation during angioplasty and that this vasoactive substance may contribute to the occurrence of vasoconstriction distal to the dilated site. Furthermore, the authors showed that the distal vasoconstriction is attenuated by intravenous ketanserin, a serotonin2-receptor antagonist. We have recently examined2,3 the effects of the intracoronary infusion of 1 mg of ketanserin on proximal and distal coronary arterial segments in 12 patients immediately after percutaneous transluminal coronary angioplasty (PTCA), in both vessels subjected to PTCA and control vessels. After PTCA, marked. © 1994, Massachusetts Medical Society. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
