Cerikan et al. devise an RNA replication-independent expression system designated pIRO (plasmid-induced replication organelle formation) phenocopying DENV/ZIKV-induced vesicle packets (VPs), the viral replication organelle. The authors find that RNA elements residing in the 3′ untranslated region of either virus genome are required for VP generation.
A Non-Replicative Role of the 3′ Terminal Sequence of the Dengue Virus Genome in Membranous Replication Organelle Formation
Cortese M.;
2020
Abstract
Cerikan et al. devise an RNA replication-independent expression system designated pIRO (plasmid-induced replication organelle formation) phenocopying DENV/ZIKV-induced vesicle packets (VPs), the viral replication organelle. The authors find that RNA elements residing in the 3′ untranslated region of either virus genome are required for VP generation.File in questo prodotto:
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