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IRIS
Background: Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD). Objectives: This study sought to investigate whether there are significant differences in complications, cardiac surgery, relapses, and mortality between IE cases in HD and non-HD patients. Methods: Prospective cohort study (International Collaboration on Endocarditis databases, encompassing 7,715 IE episodes from 2000 to 2006 and from 2008 to 2012). Descriptive analysis of baseline characteristics, epidemiological and etiological features, complications and outcomes, and their comparison between HD and non-HD patients was performed. Risk factors for major embolic events, cardiac surgery, relapses, and in-hospital and 6-month mortality were investigated in HD-patients using multivariable logistic regression. Results: A total of 6,691 patients were included and 553 (8.3%) received HD. North America had a higher HD-IE proportion than the other regions. The predominant microorganism was Staphylococcus aureus (47.8%), followed by enterococci (15.4%). Both in-hospital and 6-month mortality were significantly higher in HD versus non–HD-IE patients (30.4% vs. 17% and 39.8% vs. 20.7%, respectively; p < 0.001). Cardiac surgery was less frequently performed among HD patients (30.6% vs. 46.2%; p < 0.001), whereas relapses were higher (9.4% vs. 2.7%; p < 0.001). Risk factors for 6-month mortality included Charlson score (hazard ratio [HR]: 1.26; 95% confidence interval [CI]: 1.11 to 1.44; p = 0.001), CNS emboli and other emboli (HR: 3.11; 95% CI: 1.84 to 5.27; p < 0.001; and HR: 1.73; 95% CI: 1.02 to 2.93; p = 0.04, respectively), persistent bacteremia (HR: 1.79; 95% CI: 1.11 to 2.88; p = 0.02), and acute onset heart failure (HR: 2.37; 95% CI: 1.49 to 3.78; p < 0.001). Conclusions: HD-IE is a health care–associated infection chiefly caused by S. aureus, with increasing rates of enterococcal IE. Mortality and relapses are very high and significantly larger than in non–HD-IE patients, whereas cardiac surgery is less frequently performed.
Infective Endocarditis in Patients on Chronic Hemodialysis
Pericas J. M.;Llopis J.;Jimenez-Exposito M. J.;Kourany W. M.;Almirante B.;Carosi G.;Durante-Mangoni E.;Fortes C. Q.;Giannitsioti E.;Lerakis S.;Montagna-Mella R.;Ambrosioni J.;Tan R. -S.;Mestres C. A.;Wray D.;Pachirat O.;Moreno A.;Chu V. H.;de Lazzari E.;Fowler V. G.;Miro J. M.;Clara L.;Sanchez M.;Casabe J.;Cortes C.;Nacinovich F.;Oses P. F.;Ronderos R.;Sucari A.;Thierer J.;Altclas J.;Kogan S.;Spelman D.;Athan E.;Harris O.;Kennedy K.;Tan R.;Gordon D.;Papanicolas L.;Korman T.;Kotsanas D.;Dever R.;Jones P.;Konecny P.;Lawrence R.;Rees D.;Ryan S.;Feneley M. P.;Harkness J.;Post J.;Reinbott P.;Gattringer R.;Wiesbauer F.;Andrade A. R.;Passos de Brito A. C.;Guimaraes A. C.;Grinberg M.;Mansur A. J.;Siciliano R. F.;Varejao Strabelli T. M.;Campos Vieira M. L.;de Medeiros Tranchesi R. A.;Paiva M. G.;de Oliveira Ramos A.;Weksler C.;Ferraiuoli G.;Golebiovski W.;Lamas C.;Karlowsky J. A.;Keynan Y.;Morris A. M.;Rubinstein E.;Jones S. B.;Garcia P.;Cereceda M.;Fica A.;Mella R. M.;Fernandez R.;Franco L.;Gonzalez J.;Jaramillo A. N.;Barsic B.;Bukovski S.;Krajinovic V.;Pangercic A.;Rudez I.;Vincelj J.;Freiberger T.;Pol J.;Zaloudikova B.;Ashour Z.;El Kholy A.;Mishaal M.;Osama D.;Rizk H.;Aissa N.;Alauzet C.;Alla F.;Campagnac C. C.;Doco-Lecompte T.;Selton-Suty C.;Casalta J. -P.;Fournier P. -E.;Habib G.;Raoult D.;Thuny F.;Delahaye F.;Delahaye A.;Vandenesch F.;Donal E.;Donnio P. Y.;Flecher E.;Michelet C.;Revest M.;Tattevin P.;Chevalier F.;Jeu A.;Remadi J. P.;Rusinaru D.;Tribouilloy C.;Bernard Y.;Chirouze C.;Hoen B.;Leroy J.;Plesiat P.;Naber C.;Neuerburg C.;Mazaheri B.;Sophia Athanasia C. N.;Deliolanis I.;Giamarellou H.;Thomas T.;Mylona E.;Paniara O.;Papanicolaou K.;Pyros J.;Skoutelis A.;Papanikolaou K.;Sharma G.;Francis J.;Nair L.;Thomas V.;Venugopal K.;Hannan M. M.;Hurley J. P.;Wanounou M.;Gilon D.;Israel S.;Korem M.;Strahilevitz J.;Iossa D.;Orlando S.;Ursi M. P.;Pafundi P. C.;D'Amico F.;Bernardo M.;Dialetto G.;Covino F. E.;Manduca S.;Della Corte A.;De Feo M.;Cecchi E.;De Rosa F.;Forno D.;Imazio M.;Trinchero R.;Grossi P.;Lattanzio M.;Toniolo A.;Goglio A.;Raglio A.;Ravasio V.;Rizzi M.;Suter F.;Magri S.;Signorini L.;Kanafani Z.;Kanj S. S.;Sharif-Yakan A.;Abidin I.;Tamin S. S.;Martinez E. R.;Soto Nieto G. I.;van der Meer J. T. M.;Chambers S.;Holland D.;Morris A.;Raymond N.;Read K.;Murdoch D. R.;Dragulescu S.;Ionac A.;Mornos C.;Butkevich O. M.;Chipigina N.;Kirill O.;Vadim K.;Vinogradova T.;Edathodu J.;Halim M.;Liew Y. -Y.;Lejko-Zupanc T.;Logar M.;Mueller-Premru M.;Commerford P.;Commerford A.;Deetlefs E.;Hansa C.;Ntsekhe M.;Almela M.;Azqueta M.;Brunet M.;Castro P.;Falces C.;Fuster D.;Fita G.;Garcia- de- la- Maria C.;Garcia-Gonzalez J.;Gatell J. M.;Marco F.;Miro J. M.;Ortiz J.;Ninot S.;Pare J. C.;Pericas J. M.;Quintana E.;Ramirez J.;Rovira I.;Sandoval E.;Sitges M.;Tellez A.;Tolosana J. M.;Vidal B.;Vila J.;Anguera I.;Font B.;Guma J. R.;Bermejo J.;Bouza E.;Garcia Fernandez M. A.;Gonzalez-Ramallo V.;Marin M.;Munoz P.;Pedromingo M.;Roda J.;Rodriguez-Creixems M.;Solis J.;Fernandez-Hidalgo N.;Tornos P.;de Alarcon A.;Parra R.;Alestig E.;Johansson M.;Olaison L.;Snygg-Martin U.;Pachirat P.;Pussadhamma B.;Senthong V.;Casey A.;Elliott T.;Lambert P.;Watkin R.;Eyton C.;Klein J. L.;Bradley S.;Kauffman C.;Bedimo R.;Corey G. R.;Crowley A. L.;Douglas P.;Drew L.;Holland T.;Lalani T.;Mudrick D.;Samad Z.;Sexton D.;Stryjewski M.;Wang A.;Woods C. W.;Cantey R.;Steed L.;Dickerman S. A.;Bonilla H.;DiPersio J.;Salstrom S. -J.;Baddley J.;Patel M.;Peterson G.;Stancoven A.;Levine D.;Riddle J.;Rybak M.;Cabell C. H.
2021
Abstract
Background: Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD). Objectives: This study sought to investigate whether there are significant differences in complications, cardiac surgery, relapses, and mortality between IE cases in HD and non-HD patients. Methods: Prospective cohort study (International Collaboration on Endocarditis databases, encompassing 7,715 IE episodes from 2000 to 2006 and from 2008 to 2012). Descriptive analysis of baseline characteristics, epidemiological and etiological features, complications and outcomes, and their comparison between HD and non-HD patients was performed. Risk factors for major embolic events, cardiac surgery, relapses, and in-hospital and 6-month mortality were investigated in HD-patients using multivariable logistic regression. Results: A total of 6,691 patients were included and 553 (8.3%) received HD. North America had a higher HD-IE proportion than the other regions. The predominant microorganism was Staphylococcus aureus (47.8%), followed by enterococci (15.4%). Both in-hospital and 6-month mortality were significantly higher in HD versus non–HD-IE patients (30.4% vs. 17% and 39.8% vs. 20.7%, respectively; p < 0.001). Cardiac surgery was less frequently performed among HD patients (30.6% vs. 46.2%; p < 0.001), whereas relapses were higher (9.4% vs. 2.7%; p < 0.001). Risk factors for 6-month mortality included Charlson score (hazard ratio [HR]: 1.26; 95% confidence interval [CI]: 1.11 to 1.44; p = 0.001), CNS emboli and other emboli (HR: 3.11; 95% CI: 1.84 to 5.27; p < 0.001; and HR: 1.73; 95% CI: 1.02 to 2.93; p = 0.04, respectively), persistent bacteremia (HR: 1.79; 95% CI: 1.11 to 2.88; p = 0.02), and acute onset heart failure (HR: 2.37; 95% CI: 1.49 to 3.78; p < 0.001). Conclusions: HD-IE is a health care–associated infection chiefly caused by S. aureus, with increasing rates of enterococcal IE. Mortality and relapses are very high and significantly larger than in non–HD-IE patients, whereas cardiac surgery is less frequently performed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/451118
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
