Focus on localized laryngeal amyloidosis: management of five cases

Amyloidosis is a group of idiopathic clinicalsyndromes caused by the deposition of insolublefibrillarproteins(amyloid)in the extracellular matrix of organs andtissues. These deposits disrupt the function of the targetorgan. Amyloidosis can manifest as a systemic disease or asingle-organ involvement(local form). Its etiology stillremains unclear. Deposits of amyloid in the larynx arerare, accounting for between 0.2 and 1.2% of benign tumorsof the larynx. In this retrospective study, we report theclinical aspects, diagnosis, treatment and follow-up offivefemale patients with localized laryngeal amyloidosiswithout systemic involvement. The patients were all treatedsuccessfully using microlaryngoscopy with CO2laserorcoldinstruments. Prognosis is excellent; however, appropriatefollow-up is an important part of the long-term manage-ment of this disease in order to prevent and control thepossibility of local recurrence.