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Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF).Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples.Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest.Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS.
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
Boyle A. J.;Madotto F.;Laffey J. G.;Bellani G.;Pham T.;Pesenti A.;Thompson B. T.;O'Kane C. M.;Deane A. M.;McAuley D. F.;Rios F.;Van Haren F.;Faruq M. O.;Sottiaux T.;Depuydt P.;Lora F. S.;Azevedo L. C.;Fan E.;Bugedo G.;Qiu H.;Gonzalez M.;Silesky J.;Cerny V.;Nielsen J.;Jibaja M.;Wrigge H.;Matamis D.;Ranero J. L.;Gomersall C.;Amin P.;Hashemian S. M.;Clarkson K.;Kurahashi K.;Koh Y.;Villagomez A.;Zeggwagh A. A.;Heunks L. M.;Laake J. H.;Kashif W.;Synclair J.;Palo J. E.;do Vale Fernandes A.;Sandesc D.;Arabi Y.;Bumbasierevic V.;Nin N.;Lorente J. A.;Larsson A.;Piquilloud L.;Patjanasoontorn B.;Abroug F.;McNamee L.;Hurtado J.;Bajwa E.;Dempaire G.;Francois G. M.;Rabboni F.;Conti S.;Sula H.;Cani A.;Zazu A.;Dellera C.;Alejandro R. V.;Daldin J.;Fernandez R. O.;Cardonnet L. P.;Bettini L. R.;Bisso M. C.;Osman E. M.;Setten M. G.;Lovazzano P.;Alvarez J.;Villar V.;Pozo N. C.;Grubissich N.;Plotnikow G. A.;Vasquez D. N.;Ilutovich S.;Tiribelli N.;Chena A.;Pellegrini C. A.;Saenz M. G.;Estenssoro E.;Brizuela M.;Gianinetto H.;Gomez P. E.;Cerrato V. I.;Bezzi M. G.;Borello S. A.;Loiacono F. A.;Fernandez A. M.;Knowles S.;Reynolds C.;Inskip D. M.;Miller J. J.;Kong J.;Whitehead C.;Bihari S.;Seven A.;Krstevski A.;Rodgers H. J.;Millar R. T.;Mckenna T. E.;Bailey I. M.;Hanlon G. C.;Aneman A.;Lynch J. M.;Azad R.;Neal J.;Woods P. W.;Roberts B. L.;Kol M. R.;Wong H. S.;Riss K. C.;Staudinger T.;Wittebole X.;Bulpa P. A.;Dive A. M.;Verstraete R.;Lebbinck H.;Vermassen J.;Philippe M.;Ceunen H.;Rosa J. I.;Beraldo D. O.;Piras C.;Rampinelli A. M.;Nassar A. P.;Mataloun S.;Moock M.;Thompson M. M.;Goncalves C. H.;Antonio ACP.;Ascoli A.;Biondi R. S.;Fontenele D. C.;Nobrega D.;Sales V. M.;Shindhe S.;Pg Hj Ismail DMAB.;Beloncle F.;Davies K. G.;Cirone R.;Manoharan V.;Ismail M.;Goligher E. C.;Jassal M.;Ferguson N. D.;Nishikawa E.;Javeed A.;Curley G.;Rittayamai N.;Parotto M.;Mehta S.;Knoll J.;Pronovost A.;Bruhn SCAR.;Garcia P. H.;Aliaga F. A.;Farias P. A.;Yumha J. S.;Ortiz C. A.;Salas J. E.;Saez A. A.;Vega L. D.;Labarca E. F.;Martinez F. T.;Carreno N. G.;Lora P.;Liu H.;Liu L.;Tang R.;Luo X.;An Y.;Zhao H.;Gao Y.;Zhai Z.;Ye Z. L.;Wang W.;Li W.;Li Q.;Zheng R.;Yu W.;Shen J.;Li X.;Yu T.;Lu W.;Wu Y. Q.;Huang X. B.;He Z.;Lu Y.;Han H.;Zhang F.;Sun R.;Wang H. X.;Qin S. H.;Zhu B. H.;Zhao J.;Liu J.;Li B.;Liu J. L.;Zhou F. C.;Li Q. J.;Zhang X. Y.;Li-Xin Z.;Xin-Hua Q.;Jiang L.;Gao Y. N.;Zhao X. Y.;Li Y. Y.;Li X. L.;Wang C.;Yao Q.;Yu R.;Chen K.;Shao H.;Qin B.;Huang Q. Q.;Zhu W. H.;Hang A. Y.;Hua M. X.;Li Y.;Xu Y.;Di Y. D.;Ling L. L.;Qin T. H.;Wang S. H.;Qin J.;Han Y.;Zhou S.;Vargas M. P.;Silesky Jimenez J. I.;Gonzalez Rojas M. A.;Solis-Quesada J. E.;Ramirez-Alfaro C. M.;Maca J.;Sklienka P.;Gjedsted J.;Christiansen A.;Rigshopitalet;Villamagua B. G.;Llano M.;Burtin P.;Buzancais G.;Beuret P.;Pelletier N.;Mortaza S.;Mercat A.;Chelly J.;Jochmans S.;Terzi N.;Daubin C.;Carteaux G.;de Prost N.;Chiche J. D.;Daviaud F.;Fartoukh M.;Barberet G.;Biehler J.;Dellamonica J.;Doyen D.;Arnal J. M.;Briquet A.;Klasen F.;Papazian L.;Follin A.;Roux D.;Messika J.;Kalaitzis E.;Dangers L.;Combes A.;Au S. M.;Beduneau G.;Carpentier D.;Zogheib E. H.;Dupont H.;Ricome S.;Santoli F. L.;Besset S. L.;Michel P.;Gelee B.;Danin P. E.;Goubaux B.;Crova P. J.;Phan N. T.;Berkelmans F.;Badie J. C.;Tapponnier R.;Gally J.;Khebbeb S.;Herbrecht J. E.;Schneider F.;Declercq P. M.;Rigaud J. P.;Duranteau J.;Harrois A.;Chabanne R.;Marin J.;Constantin J. M.;Thibault S.;Ghazi M.;Boukhazna M.;Zein S. O.;Richecoeur J. R.;Combaux D. M.;Grelon F.;Le Moal C.;Sauvadet E. P.;Robine A.;Lemiale V.;Reuter D.;Dres M.;Demoule A.;Goldgran-Toledano D.;Baboi L.;Guerin C.;Lohner R.;Krassler J.;Schafer S.;Zacharowski K. D.;Meybohm P.;Reske A. W.;Simon P.;Hopf H. F.;Schuetz M.;Baltus T.;Papanikolaou M. N.;Papavasilopoulou T. G.;Zacharas G. A.;Ourailogloy V.;Mouloudi E. K.;Massa E. V.;Nagy E. O.;Stamou E. E.;Kiourtzieva E. V.;Oikonomou M. A.;Avila L. E.;Cortez C. A.;Citalan J. E.;Jog S. A.;Sable S. D.;Shah B.;Gurjar M.;Baronia A. K.;Memon M.;Muthuchellappan R.;Ramesh V. J.;Shenoy A.;Unnikrishnan R.;Dixit S. B.;Rhayakar R. V.;Ramakrishnan N.;Bhardwaj V. K.;Mahto H. L.;Sagar S. V.;Palaniswamy V.;Ganesan D.;Jamaati H.;Heidari F.;Meaney E. A.;Nichol A.;Knapman K. M.;O'Croinin D.;Dunne E. S.;Breen D. M.;Clarkson K. P.;Jaafar R. F.;Dwyer R.;Amir F.;Ajetunmobi O. O.;O'Muircheartaigh A. C.;Black C. S.;Treanor N.;Collins D. V.;Altaf W.;Zani G.;Fusari M.;Spadaro S.;Volta C. A.;Graziani R.;Brunettini B.;Palmese S.;Formenti P.;Umbrello M.;Lombardo A.;Pecci E.;Botteri M.;Savioli M.;Protti A.;Mattei A.;Schiavoni L.;Tinnirello A.;Todeschini M.;Giarratano A.;Cortegiani A.;Sher S.;Rossi A.;Antonelli M. M.;Montini L. M.;Casalena P.;Scafetti S.;Panarello G.;Occhipinti G.;Patroniti N.;Pozzi M.;Biscione R. R.;Poli M. M.;Raimondi F.;Albiero D.;Crapelli G.;Beck E.;Pota V.;Schiavone V.;Molin A.;Tarantino F.;Monti G.;Frati E.;Mirabella L.;Cinnella G.;Fossali T.;Colombo R.;Pattarino PTI.;Mojoli F.;Braschi A.;Borotto E. E.;Cracchiolo A. N.;Palma D. M.;Raponi F.;Foti G.;Vascotto E. R.;Coppadoro A.;Brazzi L.;Floris L.;Iotti G. A.;Venti A.;Yamaguchi O.;Takagi S.;Maeyama H. N.;Watanabe E.;Yamaji Y.;Shimizu K.;Shiozaki K.;Futami S.;Ryosuke S.;Saito K.;Kameyama Y.;Ueno K.;Izawa M.;Okuda N.;Suzuki H.;Harasawa T.;Nasu M.;Takada T.;Ito F.;Nunomiya S.;Koyama K.;Abe T.;Andoh K.;Kusumoto K.;Hirata A.;Takaba A.;Kimura H.;Matsumoto S.;Higashijima U.;Honda H.;Aoki N.;Imai H.;Ogino Y.;Mizuguchi I.;Ichikado K.;Nitta K.;Mochizuki K.;Hashida T.;Tanaka H.;Nakamura T.;Niimi D.;Ueda T.;Kashiwa Y.;Uchiyama A.;Sabelnikovs O.;Oss P.;Haddad Y.;Liew K. Y.;Namendys-Silva S. A.;Jarquin-Badiola Y. D.;Sanchez-Hurtado L. A.;Gomez-Flores S. S.;Marin M. C.;Villagomez A. J.;Lemus J. S.;Fierro J. M.;Cervantes M. R.;Mejia FJF.;Dector D.;Dector D. M.;Gonzalez D. R.;Estrella C. R.;Sanchez-Medina J. R.;Ramirez-Gutierrez A.;George F. G.;Aguirre J. S.;Buensuseso J. A.;Poblano M.;Dendane T.;Balkhi H.;Elkhayari M.;Samkaoui N.;Ezzouine H.;Benslama A.;Amor M.;Maazouzi W.;Cimic N.;Beck O.;Bruns M. M.;Schouten J. A.;Rinia M.;Raaijmakers M.;Van Wezel H. M.;Heines S. J.;Strauch U.;Buise M. P.;Simonis F. D.;Schultz M. J.;Goodson J. C.;Browne T. S.;Navarra L.;Hunt A.;Hutchison R. A.;Bailey M. B.;Newby L.;Mcarthur C.;Kalkoff M.;Mcleod A.;Casement J.;Hacking D. J.;Andersen F. H.;Dolva M. S.;Barratt-Due A.;Noremark KAL.;Soreide E.;Sjobo B. A.;Guttormsen A. B.;Leon Yoshido H. H.;Aguilar R. Z.;Montes Oscanoa F. A.;Alisasis A. U.;Robles J. B.;Pasanting-Lim RAB.;Tan B. C.;Andruszkiewicz P.;Jakubowska K.;Coxo C. M.;Alvarez A. M.;Oliveira B. S.;Montanha G. M.;Barros N. C.;Pereira C. S.;Messias A. M.;Monteiro J. M.;Araujo A. M.;Catorze N. T.;Marum S. M.;Bouw M. J.;Gomes R. M.;Brito V. A.;Castro S.;Estilita J. M.;Barros F. M.;Serra I. M.;Martinho A. M.;Tomescu D. R.;Marcu A.;Bedreag O. H.;Papurica M.;Corneci D. E.;Negoita S. I.;Grigoriev E.;Gritsan A. I.;Gazenkampf A. A.;Almekhlafi G.;Albarrak M. M.;Mustafa G. M.;Maghrabi K. A.;Salahuddin N.;Aisa T. M.;Al Jabbary A. S.;Tabhan E.;Arabi Y. M.;Trinidad O. A.;Al Dorzi H. M.;Tabhan E. E.;Bolon S.;Smith O.;Mancebo J.;Aguirre-Bermeo H.;Lopez-Delgado J. C.;Esteve F.;Rialp G.;Forteza C.;De Haro C.;Artigas A.;Albaiceta G. M.;De Cima-Iglesias S.;Seoane-Quiroga L.;Ceniceros-Barros A.;Ruiz-Aguilar A. L.;Claraco-Vega L. M.;Soler J. A.;Del Carmen Lorente M.;Hermosa C.;Gordo F.;Prieto-Gonzalez M.;Lopez-Messa J. B.;Perez M. P.;Perez C. P.;Allue R. M.;Roche-Campo F.;Ibanez-Santacruz M.;Temprano S.;Pintado M. C.;De Pablo R.;Gomez PRA.;Ruiz S. R.;Moles S. I.;Jurado M. T.;Arizmendi A.;Piacentini E. A.;Franco N.;Honrubia T.;Cheng M. P.;Losada E. P.;Blanco J.;Yuste L. J.;Carbayo-Gorriz C.;Cazorla-Barranquero F. G.;Alonso J. G.;Alda R. S.;Algaba A.;Navarro G.;Cereijo E.;Diaz-Rodriguez E.;Marcos D. P.;Montero L. A.;Para L. H.;Sanchez R. J.;Navalpotro MAB.;Abad R. D.;Gonzalez R. M.;Toribio D. P.;Castro A. G.;Artiga MJD.;Penuelas O.;Roser T. P.;Olga M. F.;Curto E. G.;Sanchez R. M.;Imma V. P.;Elisabet G. M.;Claverias L.;Magret M.;Pellicer A. M.;Rodriguez L. L.;Sanchez-Ballesteros J.;Gonzalez-Salamanca A.;Jimenez A. G.;Huerta F. P.;Llinares Moya D. D.;Tallet Alfonso A. A.;Luis PSE.;Cesar P. S.;Rafael S. I.;Virgilio C. G.;Recio N. N.;Adamsson R. O.;Rylander C. C.;Holzgraefe B.;Broman L. M.;Wessbergh J.;Persson L.;Schioler F.;Kedelv H.;Tibblin A. O.;Appelberg H.;Hedlund L.;Helleberg J.;Eriksson K. E.;Glietsch R.;Larsson N.;Nygren I.;Nunes S. L.;Morin A. K.;Kander T.;Adolfsson A.;Zender H. O.;Leemann-Refondini C.;Elatrous S.;Bouchoucha S.;Chouchene I.;Ouanes I.;Souissi A. B.;Kamoun S.;Demirkiran O.;Aker M.;Erbabacan E.;Ceylan I.;Girgin N. K.;Ozcelik M.;Unal N.;Meco B. C.;Akyol O. O.;Derman S. S.;Kennedy B.;Parhar K.;Srinivasa L.;Hopkins P.;Mellis C.;Kakar V.;Hadfield D.;Vercueil A.;Bhowmick K.;Humphreys S. K.;Ferguson A.;Mckee R.;Raj A. S.;Fawkes D. A.;Watt P.;Twohey L.;JhaMatthew Thomas R. R.;Morton A.;Kadaba V.;Smith M. J.;Hormis A. P.;Kannan S. G.;Namih M.;Reschreiter H.;Camsooksai J.;Kumar A.;Rugonfalvi S.;Nutt C.;Oneill O.;Seasman C.;Dempsey G.;Scott C. J.;Ellis H. E.;Mckechnie S.;Hutton P. J.;Di Tomasso N. N.;Vitale M. N.;Griffin R. O.;Dean M. N.;Cranshaw J. H.;Willett E. L.;Ioannou N.;Gillis S.;Csabi P.;Macfadyen R.;Dawson H.;Preez P. D.;Williams A. J.;Boyd O.;De Gordoa L. O.;Bramall J.;Symmonds S.;Chau S. K.;Wenham T.;Szakmany T.;Toth-Tarsoly P.;Mccalman K. H.;Alexander P.;Stephenson L.;Collyer T.;Chapman R.;Cooper R.;Allan R. M.;Sim M.;Wrathall D. W.;Irvine D. A.;Zantua K. S.;Adams J. C.;Burtenshaw A. J.;Sellors G. P.;Welters I. D.;Williams K. E.;Hessell R. J.;Oldroyd M. G.;Battle C. E.;Pillai S.;Kajtor I.;Sivashanmugavel M.;Okane S. C.;Donnelly A.;Frigyik A. D.;Careless J. P.;May M. M.;Stewart R.;John Trinder T.;Hagan S. J.;Wise M. P.;Cole J. M.;MacFie C. C.;Dowling A. T.;Nunez E.;Pittini G.;Rodriguez R.;Imperio M. C.;Santos C.;Franca A. G.;Ebeid A.;Deicas A.;Serra C.;Uppalapati A.;Kamel G.;Banner-Goodspeed V. M.;Beitler J. R.;Mukkera S. R.;Kulkarni S.;Lee J.;Mesar T.;Shinn Iii J. O.;Gomaa D.;Tainter C.;Yeatts D. J.;Warren J.;Lanspa M. J.;Miller R. R.;Grissom C. K.;Brown S. M.;Bauer P. R.;Gosselin R. J.;Kitch B. T.;Cohen J. E.;Beegle S. H.;Gueret R. M.;Tulaimat A.;Choudry S.;Stigler W.;Batra H.;Huff N. G.;Lamb K. D.;Oetting T. W.;Mohr N. M.;Judy C.;Saito S.;Kheir F. M.;Kheir F.;Schlichting A. B.;Delsing A.;Crouch D. R.;Elmasri M.;Ismail D.;Dreyer K. R.;Blakeman T. C.;Baron R. M.;Grijalba C. Q.;Hou P. C.;Seethala R.;Aisiku I.;Henderson G.;Frendl G.;Hou S. K.;Owens R. L.;Schomer A.;Bumbasirevic V.;Jovanovic B.;Surbatovic M.;Veljovic M.
2018
Abstract
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF).Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples.Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest.Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/420123
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
