Objective: Recent studies demonstrated a significant association between sarcopenia and severe osteoporosis in older women. 1 However, the decline in muscle performance and mobility limitation are due only in part to the age-related reduction of muscle mass.2 The dynapenic skeletal muscle function deficit (SMFD) is a new terminology used to integrate the age-related muscle dysfunctions. The aim of our study was to investigate this concept in a cohort of postmenopausal women. Materials and methods: In this retrospective study we analyzed data derived from the medical record of postmenopausal women aged 55 or older referring to an outpatient rehabilitation service. In our population, we defined dynapenic SMFD according to the Foundation for the National Institutes of Health’s (FNIH) criteria,2 based on reduction of usual gait speed (<0.8 m/s), handgrip strength (<16 kg), and normal appendicular lean mass adjusted for BMI (>0.512). We analyzed the Vertebral Fracture Assessment (VFA) from DXA spine images to identify vertebral fragility fractures. Results: Shown in the table. In our cohort, women with dynapenic SMFD had an odds ratio (OR), adjusted for age, for vertebral fragility fracture of 1.79 (95 %CI=1.40–3.68; p=0.044). Population Non- dynapenic SMFD Dynapenic SMFD p-value (n=70) (n=45) (n=25) Age 67±7.71 64.73±1.10 71.08±1.34 <0.001 BMI (kg/m2) 25.21±3.34 25.13±0.52 25.34±0.64 0.80 Falls (n) 13 (18.57 %) 8 (17.78 %) 5 (20 %) 0.82 VFx (n) 36 (51.43 %) 17 (37.78 %) 19 (76 %) 0.002 BMD L1-L4 (g/cm2) 0.893±0.203 0.871±0.031 0.934±0.038 0.23 Note: data are expressed as mean±SD. Abbreviations: BMI=body mass index; VFx=vertebral fragility fractures; BMD=Bone Mineral Density; SMFD=Skeletal Muscle Fucntion Deficit. Conclusion: In our opinion, the concept of dynapenic SMFD might be useful to provide a comprehensive assessment of the risk fracture in osteoporotic women. References: 1. Iolascon G et al., Aging Clin Exp Res 2013;25 Suppl 1:S129. 2. Studenski SA et al., J Gerontol A Biol Sci Med Sci 2014;69:547.
P511 DYNAPENIC SKELETAL MUSCLE FUNCTION DEFICIT AS DETERMINANT OF SKELETAL FRAGILITY: A RETROSPECTIVE ANALYSIS
Moretti A;F Gimigliano;G Iolascon
2015
Abstract
Objective: Recent studies demonstrated a significant association between sarcopenia and severe osteoporosis in older women. 1 However, the decline in muscle performance and mobility limitation are due only in part to the age-related reduction of muscle mass.2 The dynapenic skeletal muscle function deficit (SMFD) is a new terminology used to integrate the age-related muscle dysfunctions. The aim of our study was to investigate this concept in a cohort of postmenopausal women. Materials and methods: In this retrospective study we analyzed data derived from the medical record of postmenopausal women aged 55 or older referring to an outpatient rehabilitation service. In our population, we defined dynapenic SMFD according to the Foundation for the National Institutes of Health’s (FNIH) criteria,2 based on reduction of usual gait speed (<0.8 m/s), handgrip strength (<16 kg), and normal appendicular lean mass adjusted for BMI (>0.512). We analyzed the Vertebral Fracture Assessment (VFA) from DXA spine images to identify vertebral fragility fractures. Results: Shown in the table. In our cohort, women with dynapenic SMFD had an odds ratio (OR), adjusted for age, for vertebral fragility fracture of 1.79 (95 %CI=1.40–3.68; p=0.044). Population Non- dynapenic SMFD Dynapenic SMFD p-value (n=70) (n=45) (n=25) Age 67±7.71 64.73±1.10 71.08±1.34 <0.001 BMI (kg/m2) 25.21±3.34 25.13±0.52 25.34±0.64 0.80 Falls (n) 13 (18.57 %) 8 (17.78 %) 5 (20 %) 0.82 VFx (n) 36 (51.43 %) 17 (37.78 %) 19 (76 %) 0.002 BMD L1-L4 (g/cm2) 0.893±0.203 0.871±0.031 0.934±0.038 0.23 Note: data are expressed as mean±SD. Abbreviations: BMI=body mass index; VFx=vertebral fragility fractures; BMD=Bone Mineral Density; SMFD=Skeletal Muscle Fucntion Deficit. Conclusion: In our opinion, the concept of dynapenic SMFD might be useful to provide a comprehensive assessment of the risk fracture in osteoporotic women. References: 1. Iolascon G et al., Aging Clin Exp Res 2013;25 Suppl 1:S129. 2. Studenski SA et al., J Gerontol A Biol Sci Med Sci 2014;69:547.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
