Background: Post-menopausal women generally present reduced serum levels of vitamin D, reduced VDR expression in skeletal muscle cells, and a gradual loss of muscle mass and muscle function. The relationship between serum 25-hydroxyvitamin D [25(OH)D3] levels and muscle strength has been extensively investigated, even though there is no agreement in literature. Therefore, aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physical performance in post-menopausal women, comparing calcifediol and cholecalciferol. Material and methods: In this prospective study we included postmenopausal women, dividing them into two groups, according to the prescription performed (calcifediol or cholecalciferol). We evaluated at the baseline (T0) and after 6 months (T1): serum levels of 25(OH)D3, appendicular muscle strength, using the Hand Grip Strength Test (HGS) and the Knee Extensor Strength Test (KES), and physical performance, using the Short Physical Performance Battery (SPPB). Results: We evaluated 205 post-menopausal women, mean aged 6928±916 years, 103 treated with calcifediol and 102 with cholecalciferol. In Table 1 we showed the results. Table 1 Outcome measures assessed at the baseline and after 6 months of vitamin D supplementation. Calcifediol T0 (n=103) Calcifediol T1 (n=103) P values 25(OH)D3 (ng/ml) 31.74±13.03 51.80±19.85 <0.001 HGS (kg) 15.54±6.65 18.29±3.85 0.014 KES (kg) 14.49±6.92 17.05±5.62 0.050 SPPB 8.41±3.32 9.70±2.14 0.008 Cholecalciferol T0 (n=102) Cholecalciferol T1 (n=102) P values 25(OH)D3 (ng/ml) 35.15±11.57 40.28±13.04 0.118 HGS (kg) 15,36±6.06 16.38±5.14 0.257 KES (kg) 12.12±5.74 12.58±5.67 0.627 SPPB 7.81±3.66 8.02±3.41 0.638 Results are expressed as means±S.D. Analysis was performed using a paired t-test. Conclusions: Our results showed that post-menopausal women treated with calcifediol had significant improvements in serum levels of 25(OH)D3, muscle strength, and physical performance.

Effects of calcifediol versus cholecalciferol on 25(OH)D3 serum levels, appendicular muscle strength, and physical performance in post-menopausal women

Moretti A;Francesca Gimigliano;Giovanni Iolascon
2016

Abstract

Background: Post-menopausal women generally present reduced serum levels of vitamin D, reduced VDR expression in skeletal muscle cells, and a gradual loss of muscle mass and muscle function. The relationship between serum 25-hydroxyvitamin D [25(OH)D3] levels and muscle strength has been extensively investigated, even though there is no agreement in literature. Therefore, aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physical performance in post-menopausal women, comparing calcifediol and cholecalciferol. Material and methods: In this prospective study we included postmenopausal women, dividing them into two groups, according to the prescription performed (calcifediol or cholecalciferol). We evaluated at the baseline (T0) and after 6 months (T1): serum levels of 25(OH)D3, appendicular muscle strength, using the Hand Grip Strength Test (HGS) and the Knee Extensor Strength Test (KES), and physical performance, using the Short Physical Performance Battery (SPPB). Results: We evaluated 205 post-menopausal women, mean aged 6928±916 years, 103 treated with calcifediol and 102 with cholecalciferol. In Table 1 we showed the results. Table 1 Outcome measures assessed at the baseline and after 6 months of vitamin D supplementation. Calcifediol T0 (n=103) Calcifediol T1 (n=103) P values 25(OH)D3 (ng/ml) 31.74±13.03 51.80±19.85 <0.001 HGS (kg) 15.54±6.65 18.29±3.85 0.014 KES (kg) 14.49±6.92 17.05±5.62 0.050 SPPB 8.41±3.32 9.70±2.14 0.008 Cholecalciferol T0 (n=102) Cholecalciferol T1 (n=102) P values 25(OH)D3 (ng/ml) 35.15±11.57 40.28±13.04 0.118 HGS (kg) 15,36±6.06 16.38±5.14 0.257 KES (kg) 12.12±5.74 12.58±5.67 0.627 SPPB 7.81±3.66 8.02±3.41 0.638 Results are expressed as means±S.D. Analysis was performed using a paired t-test. Conclusions: Our results showed that post-menopausal women treated with calcifediol had significant improvements in serum levels of 25(OH)D3, muscle strength, and physical performance.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/419656
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact