Objective: The aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physical performance in postmenopausal women, comparing calcifediol and cholecalciferol. Material and Methods: In our real-practice study we included postmenopausal women aged ≥50 y; they were divided into two groups, according to the prescription: calcifediol and cholecalciferol. We evaluated at the baseline (T0) and after six months (T1): serumlevels of 25(OH)D3, appendicular muscle strength, using the hand grip strength test (HGS) and the knee extensor strength test (KES), and physical performance, using the short physical performance battery (SPPB). Results: We evaluated 205 postmenopausal women, mean aged 69.28 ± 9.16 years, 103 treated with calcifediol and 102 with cholecalciferol. In Table 1 we showed the results after vitamin D prescription. Table 1. Outcome measures assessed at the baseline and after 6 months of vitamin D supplementation. Calcifediol T0 (n = 103) Calcifediol T1 (n = 103) Pvalues 25(OH)D3 (ng/ml) 31.74 ± 13.03 51.80 ± 19.85 <0.001 HGS (kg) 15.54 ± 6.65 18.29 ± 3.85 0.014 KES (kg) 14.49 ± 6.92 17.05 ± 5.62 0.050 SPPB 8.41 ± 3.32 9.70 ± 2.14 0.008 Cholecalciferol T0 (n = 102) Cholecalciferol T1 (n = 102) Pvalues 25(OH)D3 (ng/ml) 35.15 ± 11.57 40.28 ± 13.04 0.118 HGS (kg) 15,36 ± 6.06 16.38 ± 5.14 0.257 KES (kg) 12.12 ± 5.74 12.58 ± 5.67 0.627 SPPB 7.81 ± 3.66 8.02 ± 3.41 0.638 Result are expressed as means ± standard deviations. Within group analysis was performed using a paired t-test Conclusions: Our results showed that postmenopausal women treated with calcifediol had significant improvements in serum levels of 25(OH)D3, muscle strength, and physical performance.

P230 IS CALCIFEDIOL MORE EFFECTIVE THAN CHOLECALCIFEROL IN IMPROVING 25-HYDROXYVITAMIN D3 LEVELS, MUSCLE STRENGTH, AND PHYSICAL PERFORMANCE IN POSTMENOPAUSALWOMEN?

Moretti A;G. Iolascon
2016

Abstract

Objective: The aim of our study was to evaluate the effects of vitamin D on 25(OH)D3 levels, muscle strength, and physical performance in postmenopausal women, comparing calcifediol and cholecalciferol. Material and Methods: In our real-practice study we included postmenopausal women aged ≥50 y; they were divided into two groups, according to the prescription: calcifediol and cholecalciferol. We evaluated at the baseline (T0) and after six months (T1): serumlevels of 25(OH)D3, appendicular muscle strength, using the hand grip strength test (HGS) and the knee extensor strength test (KES), and physical performance, using the short physical performance battery (SPPB). Results: We evaluated 205 postmenopausal women, mean aged 69.28 ± 9.16 years, 103 treated with calcifediol and 102 with cholecalciferol. In Table 1 we showed the results after vitamin D prescription. Table 1. Outcome measures assessed at the baseline and after 6 months of vitamin D supplementation. Calcifediol T0 (n = 103) Calcifediol T1 (n = 103) Pvalues 25(OH)D3 (ng/ml) 31.74 ± 13.03 51.80 ± 19.85 <0.001 HGS (kg) 15.54 ± 6.65 18.29 ± 3.85 0.014 KES (kg) 14.49 ± 6.92 17.05 ± 5.62 0.050 SPPB 8.41 ± 3.32 9.70 ± 2.14 0.008 Cholecalciferol T0 (n = 102) Cholecalciferol T1 (n = 102) Pvalues 25(OH)D3 (ng/ml) 35.15 ± 11.57 40.28 ± 13.04 0.118 HGS (kg) 15,36 ± 6.06 16.38 ± 5.14 0.257 KES (kg) 12.12 ± 5.74 12.58 ± 5.67 0.627 SPPB 7.81 ± 3.66 8.02 ± 3.41 0.638 Result are expressed as means ± standard deviations. Within group analysis was performed using a paired t-test Conclusions: Our results showed that postmenopausal women treated with calcifediol had significant improvements in serum levels of 25(OH)D3, muscle strength, and physical performance.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/419638
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