The Relationships Between Cognitive Reserve and Psychological Symptoms: A Cross-Sectional Study in Healthy Individuals

Objectives: Low levels of cognitive reserve (CR), depressive symptomatology, and apathy are considered risk factors for cognitive decline. The aim of this study was to explore the relationships between these factors across the lifespan in healthy adults. Methods: This study included 429 Italian participants with no cognitive impairment, divided in three age subgroups: young adults, adults, and elderly. Participants were categorized as having low- or high CR based on the median of the Cognitive Reserve Scale, a self-rated questionnaire evaluating engagement in several leisure and social activities. Depressive symptomatology and severity of apathy were assessed by the Beck Depression Inventory – second edition (BDI-II) and the Dimensional Apathy Scale (DAS), respectively. Analysis of variance and regression served to explore the association between CR, apathy, and depression in the whole sample and in the three age subgroups. Results: The analyses of variance and regression analyses revealed that DAS was associated with I-CRS scores in all age groups, as people with high levels of lifetime CR showed a lower level of apathy, whereas no association was found between BDI-II and I-CRS scores. Conclusion: Lifetime CR is associated with levels of apathy, but not of depressive symptomatology. Low CR is strongly associated with high levels of apathy and might indicate the need for psychoeducational interventions in order to prevent development of cognitive deterioration.