Investigations of Willow Mistletoe on Various Human Tumor Cell Lines in vitro

Traditionally, pharmaceutically produced mistletoe preparations from willow tree are often used for treating bladder and renal cell carcinomas. However, only little data from preparations from willow mistletoe have been published so far and the underlying mechanisms are not completely known. The inhibitory effects of an extract from mistletoe from willow tree (Iscucin ® Salicis) on the viability of cancer cells and feasible mechanisms were investigated using different assays. Furthermore, the inhibition of cell migration was analysed. Results The extract inhibited cell growth and migration in vitro, with varying intensity depending on the respective cell line. Especially neuro-epithelial tumor cells and bronchial carcinoma cells showed a good response. Moreover, pro-apoptotic markers were activated. Clinical investigations should clarify, which types of cancer have the highest potential for a treatment with Iscucin ® Salicis.