Systemic sclerosis (SSc) is a heterogeneous connective tissue disease. The usual subclassification divides patients into limited (lc) and diffuse cutaneous (dc) subsets relying on the skin extension but may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database is a prospective cohort providing data from 137 European referral centers. We performed a cluster analysis to distinguish and characterize homogeneous phenotypes without any a priori, and examined survival among the obtained clusters.
Phenotypes determined by cluster analysis and their survival in the prospective EUSTAR cohort of patients with systemic sclerosis
Vettori, Serena;Giovanna Cuomo
2019
Abstract
Systemic sclerosis (SSc) is a heterogeneous connective tissue disease. The usual subclassification divides patients into limited (lc) and diffuse cutaneous (dc) subsets relying on the skin extension but may not capture the entire variability of clinical phenotypes. The European Scleroderma Trials and Research (EUSTAR) database is a prospective cohort providing data from 137 European referral centers. We performed a cluster analysis to distinguish and characterize homogeneous phenotypes without any a priori, and examined survival among the obtained clusters.File in questo prodotto:
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