The neuropeptides orexin A and B (hypocretin 1 and 2) are produced by one group of neurons located in the lateral hypothalamic area. These neurons receive a variety of signals related to environmental, physiological and emotional stimuli. In turn, they send axons to numerous brain regions implicated in the regulation of the sleep-wake cycle, thereby increasing arousal levels and maintaining wakefulness. Dysregulation or loss of orexin signaling has been linked to a number of pathological conditions. In this review, we present an overview of the current understanding of orexin function, focusing on evidence for the involvement of orexin in sleep disorders and neurodegenerative diseases.

Involvement of orexin in sleep disorders and neurodegenerative diseases

CHIEFFI, Sergio;Villano, Ines;MESSINA, Antonietta;MONDA, Marcellino
2015

Abstract

The neuropeptides orexin A and B (hypocretin 1 and 2) are produced by one group of neurons located in the lateral hypothalamic area. These neurons receive a variety of signals related to environmental, physiological and emotional stimuli. In turn, they send axons to numerous brain regions implicated in the regulation of the sleep-wake cycle, thereby increasing arousal levels and maintaining wakefulness. Dysregulation or loss of orexin signaling has been linked to a number of pathological conditions. In this review, we present an overview of the current understanding of orexin function, focusing on evidence for the involvement of orexin in sleep disorders and neurodegenerative diseases.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/376048
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? ND
social impact