We evaluated the in vitro effect of growth hormone (GH), prolactin (PRL) and insulin treatment of human monocytes on Herpes simplex virus type 1 (HSV-1) infection. GH and PRL increased cell susceptibility to infection which was related to a slight TNF-α expression and release. Insulin had no significant effect. Cells activated with lipopolysaccharide (LPS) and then treated with PRL showed a lower susceptibility to HSV infection related to a significant increase in TNF-α expression and release. On the contrary, GH and insulin increased the susceptibility to infection of activated cells but did not modify TNF-α expression with respect to cells treated only with hormones.

TNF-α expression and herpes simplex infection in human monocytes treated with growth hormone, prolactin and insulin

FOLGORE, Antonio;DONNARUMMA, Giovanna;
1998

Abstract

We evaluated the in vitro effect of growth hormone (GH), prolactin (PRL) and insulin treatment of human monocytes on Herpes simplex virus type 1 (HSV-1) infection. GH and PRL increased cell susceptibility to infection which was related to a slight TNF-α expression and release. Insulin had no significant effect. Cells activated with lipopolysaccharide (LPS) and then treated with PRL showed a lower susceptibility to HSV infection related to a significant increase in TNF-α expression and release. On the contrary, GH and insulin increased the susceptibility to infection of activated cells but did not modify TNF-α expression with respect to cells treated only with hormones.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/361821
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