Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge.
1,2,3-Triazole Bridge as Conformational Constrain in -Hairpin Peptides: Analysis of Hydrogen-Bonded Positions
FATTORUSSO, Roberto;D'ANDREA, LUCA DOMENICO
2016
Abstract
Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge.File in questo prodotto:
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