Arg72Pro is a polymorphism commonly occurring in the proline-rich domain of Tp53. It can determine the development of different types of cancers, such as breast, lung, cervical, colorectal and hepatocellular carcinoma. Previous studies reported a correlation between Pro72 homozygosity and the clinical course of ulcerative colitis (UC). Our aim was to evaluate Arg72Pro genotype in patients who underwent proctocolectomy with ileo-pouch-anal anastomosis (IPAA) for UC compared with those who did not need surgery.

Arg72Pro polymorphism of p53 may predict poor response to medical treatment in ulcerative colitis

VIETRI, Maria Teresa;RIEGLER, Gabriele;Pellino, Gianluca;MOLINARI, Anna Maria;CIOFFI, Michele
2014

Abstract

Arg72Pro is a polymorphism commonly occurring in the proline-rich domain of Tp53. It can determine the development of different types of cancers, such as breast, lung, cervical, colorectal and hepatocellular carcinoma. Previous studies reported a correlation between Pro72 homozygosity and the clinical course of ulcerative colitis (UC). Our aim was to evaluate Arg72Pro genotype in patients who underwent proctocolectomy with ileo-pouch-anal anastomosis (IPAA) for UC compared with those who did not need surgery.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/340290
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