tBackground: Anaemia (AN) is frequently associated with inflammatory bowel diseases (IBD) and cannegatively influence the quality of life of patients.Aim: To evaluate the prevalence and causes of AN in IBD.Methods: We prospectively performed a one-year multicentre observational study including all IBD casesattending six Units. We also investigated patients’ main serological parameters.Results: The study population included 965 IBD patients (582 CD; 383 UC), of whom 142 were in-patientsand 823 out-patients. AN was diagnosed in 134 out of 965 IBD patients (14%). No significant difference inAN prevalence was observed between CD and UC. The prevalence of AN was higher in the hospitalized IBD(26% in- vs. 11.7% out-patients; p < 0.01; OR 2.2) and in active disease (CD: 34% active vs. 16% inactive;p < 0.01; OR 2.1 – UC: 26% active vs. 19% inactive; p = 0.03; OR 1.3). Iron deficiency was present in 72patients (53.7%), AN of chronic diseases in 12 (8.2%), mixed type AN in 11 (8.2%), thalassemia in 9 (6.7%),and macrocytic AN in 8 (5.9%).Conclusions: In Southern Italy, AN is common in IBD and is more frequent in active disease and hospitalizedpatients. Iron deficiency still remains the major cause of AN in IBD.
The burden of anaemia in patients with inflammatory bowel diseases
ROMANO, Marco;RIEGLER, Gabriele;SELVAGGI, Francesco;Gravina, Antonietta;Pellino, Gianluca;
2015
Abstract
tBackground: Anaemia (AN) is frequently associated with inflammatory bowel diseases (IBD) and cannegatively influence the quality of life of patients.Aim: To evaluate the prevalence and causes of AN in IBD.Methods: We prospectively performed a one-year multicentre observational study including all IBD casesattending six Units. We also investigated patients’ main serological parameters.Results: The study population included 965 IBD patients (582 CD; 383 UC), of whom 142 were in-patientsand 823 out-patients. AN was diagnosed in 134 out of 965 IBD patients (14%). No significant difference inAN prevalence was observed between CD and UC. The prevalence of AN was higher in the hospitalized IBD(26% in- vs. 11.7% out-patients; p < 0.01; OR 2.2) and in active disease (CD: 34% active vs. 16% inactive;p < 0.01; OR 2.1 – UC: 26% active vs. 19% inactive; p = 0.03; OR 1.3). Iron deficiency was present in 72patients (53.7%), AN of chronic diseases in 12 (8.2%), mixed type AN in 11 (8.2%), thalassemia in 9 (6.7%),and macrocytic AN in 8 (5.9%).Conclusions: In Southern Italy, AN is common in IBD and is more frequent in active disease and hospitalizedpatients. Iron deficiency still remains the major cause of AN in IBD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
