Chondroitin sulfate (CS) is a glycosaminoglycan found in both vertebrates and invertebrates. It is ubiquitously distributed in connective tissue extracellular matrices and on cell surfaces as CS-proteoglycan, in which the CS linear polysaccharide chain is covalently attached to a core protein. CS polysaccharide consists of a 4)-b-GlcA-(1!3)-b-GalNAc- (1! disaccharide repeating unit, with a variable sulfation pattern (GlcA=glucuronic acid, GalNAc=N-acetylgalactosamine). The position 4 or 6 (or both) of the GalNAc units is commonly sulfated, while position 2 or 3 of GlcA units is sulfated to a minor extent (Scheme 1). The sulfation pattern is tightly regulated in vivo; it is tissue- and age-specific and is considered able to encode functional information.[1]
A microbiological-chemical strategy to produce chondroitin sulfate a, c
DE ROSA, Mario;RESTAINO, Odile Francesca;SCHIRALDI, Chiara;
2011
Abstract
Chondroitin sulfate (CS) is a glycosaminoglycan found in both vertebrates and invertebrates. It is ubiquitously distributed in connective tissue extracellular matrices and on cell surfaces as CS-proteoglycan, in which the CS linear polysaccharide chain is covalently attached to a core protein. CS polysaccharide consists of a 4)-b-GlcA-(1!3)-b-GalNAc- (1! disaccharide repeating unit, with a variable sulfation pattern (GlcA=glucuronic acid, GalNAc=N-acetylgalactosamine). The position 4 or 6 (or both) of the GalNAc units is commonly sulfated, while position 2 or 3 of GlcA units is sulfated to a minor extent (Scheme 1). The sulfation pattern is tightly regulated in vivo; it is tissue- and age-specific and is considered able to encode functional information.[1]I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
