Spectroscopic identification and anti-biofilm properties of polar metabolites from the medicinal plant Helichrysum italicum against Pseudomonas aeruginosa

"Two new acylated styrylpyrones, one 5-methoxy-1(3H)-isobenzofuranone glucoside and a hydroxymethyl-. orcinol derivative, along with sixteen known aromatic metabolites, including lignans, quinic acid. derivatives low-molecular weight phenol glucosides, have been isolated from the methanol extract of. Helichrysum italicum, a medicinal plant typical of the Mediterranean vegetation. The structures of these. compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including. COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS2 analysis. Selected. compounds were evaluated for their anti-biofilm properties against Pseudomonas aeruginosa."

Two new acylated styrylpyrones, one 5-methoxy-1(3H)-isobenzofuranone glucoside and a hydroxymethyl-orcinol derivative, along with sixteen known aromatic metabolites, including lignans, quinic acid derivatives low-molecular weight phenol glucosides, have been isolated from the methanol extract of Helichrysum italicum, a medicinal plant typical of the Mediterranean vegetation. The structures of these compounds have been elucidated on the basis of extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS2 analysis. Selected compounds were evaluated for their anti-biofilm properties against Pseudomonas aeruginosa. © 2013 Elsevier Ltd. All rights reserved.