Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5′DNA-3′-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all-DNA complex. © 2004 Wiley Periodicals, Inc.

Targeting Duplex DNA with DNA-PNA Chimeras? Physico-Chemical Characterization of a Triplex DNA-PNA/DNA/DNA

MESSERE, Anna;
2004

Abstract

Targeting double-stranded DNA with homopyrimidine PNAs results in strand displacement complexes PNA/DNA/PNA rather than PNA/DNA/DNA triplex structures. Not much is known about the binding properties of DNA-PNA chimeras. A 16-mer 5′DNA-3′-p-(N)PNA(C) has been investigated for its ability to hybridize a complementary duplex DNA by DSC, CD, and molecular modeling studies. The obtained results showed the formation of a triplex structure having similar, if not slightly higher, stability compared to the same all-DNA complex. © 2004 Wiley Periodicals, Inc.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11591/235319
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