I surrogati diagnostici nella sindrome ipermobile

Background End points are findings that the researcher proposes to study the pathology. Type III Ehlers-Danlos syndrome (EDS III) shows hypermobile joints (causes of dislocations) and fragile skin (causes of scars). Objective The clinical sign of the hypermobile 3rd finger of the hand is proposed and studied as end point surrogate of EDS III. Metodi: The hypermobile 3° finger is evaluated by visual score in 1400 patients (523 men, 877 women) aged 19-65 years with several skin diseases. It is related to diagnostic findings of the EDS III as: Beighton scoring system, ultrasound test of the phalanges with Sonora Logic 400 MD and 7,5-10 MHz probe, ampleness of the passive movement, millimetric photo and dislocations. Results Patients show in 16.3134% of cases hypermobile 3° finger and in 15.9517% of cases EDS III. Correlations between subjects with hypermobility and patients with EDS III. is notable (ρ<0.0369). Conclusions The hypermobile 3rd finger of the hand is an end point surrogate because it is constant and allows an immediate evaluation. Hypermobility points out positive (increase in agility) and negative effects (dislocations, scars) and it recommended to the physician prudence in the practice and to the patient preventive measures.