Non-clonal stromal cultures, containing a variable amount of Mesenchymal Stem Cells (MSCs), can be easily isolated from a small aspirate of bone marrow and expanded in vitro. As such, these cultures are currently used as a source of putative MSCs for therapeutic purposes. Nowadays, dozens of clinical trials aim to treat a number of diseases, primarily immune system-related diseases, with MSCs. Moreover, several private companies are setting up clinical trials to exploit the immunomodulation and tissue repair properties of MSCs. Nevertheless, besides some successes, specifically in the treatment of immunological diseases, MSC therapies have experienced many failures. There are some issues to be analyses that may improve the success rate of MSC therapy. This editorial will briefly address some concerns associated with MSC transplants.
Is it Possible to Improve the Success Rate of Cellular Therapy Based on Mesenchymal Stem Cells?
GALDERISI, Umberto;MELONE, Mariarosa Anna Beatrice;
2014
Abstract
Non-clonal stromal cultures, containing a variable amount of Mesenchymal Stem Cells (MSCs), can be easily isolated from a small aspirate of bone marrow and expanded in vitro. As such, these cultures are currently used as a source of putative MSCs for therapeutic purposes. Nowadays, dozens of clinical trials aim to treat a number of diseases, primarily immune system-related diseases, with MSCs. Moreover, several private companies are setting up clinical trials to exploit the immunomodulation and tissue repair properties of MSCs. Nevertheless, besides some successes, specifically in the treatment of immunological diseases, MSC therapies have experienced many failures. There are some issues to be analyses that may improve the success rate of MSC therapy. This editorial will briefly address some concerns associated with MSC transplants.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
