The effect of diphtheria toxin on liver cell cytoplasm and mitochondria was evaluated by studying the release of malic dehydrogenase (MDH), glutamic pyruvic transaminase (GTP), and glutamic dehydrogenase (GLDH) enzyme activities from the isolated rat or guinea pig liver treated with toxin. Perfusions were prolonged for 6 hours after the addition of the toxin to the medium: 500 guinea pig MLD for rat liver perfusion, 1 guinea pig MLD for guinea pig liver perfusion. For both animal species MDH, GPT and GLDH values in perfusate samples of toxin experiments did not differ significantly from their control experiments. (25 references.)
Effect of diphtheria toxin on isolated perfused liver in vitro: preliminary observations
UTILI, Riccardo;
1974
Abstract
The effect of diphtheria toxin on liver cell cytoplasm and mitochondria was evaluated by studying the release of malic dehydrogenase (MDH), glutamic pyruvic transaminase (GTP), and glutamic dehydrogenase (GLDH) enzyme activities from the isolated rat or guinea pig liver treated with toxin. Perfusions were prolonged for 6 hours after the addition of the toxin to the medium: 500 guinea pig MLD for rat liver perfusion, 1 guinea pig MLD for guinea pig liver perfusion. For both animal species MDH, GPT and GLDH values in perfusate samples of toxin experiments did not differ significantly from their control experiments. (25 references.)File in questo prodotto:
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