Thromboembolic phenomenona have been described in patients with thalassemia major. In a multicenter, retrospective study we investigated the effect of factor V (FV Leiden), prothrombin (FII), methylene-tetrahydrofolate reductase (MTHFR), PlA2 glycoprotein IIIa (GpIIIa) and factor VII gene polymorphisms on the risk of thrombosis in thalassemic patients. A higher prevalence of the FVII H7 allele in subjects without thrombosis suggests that this genetic marker confers protection against thrombosis.
Thrombophilia in thalassemia major patients: analysis of genetic predisposing factors
PERROTTA, Silverio;
2001
Abstract
Thromboembolic phenomenona have been described in patients with thalassemia major. In a multicenter, retrospective study we investigated the effect of factor V (FV Leiden), prothrombin (FII), methylene-tetrahydrofolate reductase (MTHFR), PlA2 glycoprotein IIIa (GpIIIa) and factor VII gene polymorphisms on the risk of thrombosis in thalassemic patients. A higher prevalence of the FVII H7 allele in subjects without thrombosis suggests that this genetic marker confers protection against thrombosis.File in questo prodotto:
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