Quinine sulfate (QS), the first antimalarial agent, was derived from the cinchona tree. Interestingly, antimalarials were recently found effective as additional therapy for AIDS and other viral diseases. The antiviral action of some drugs is associated with the induction of heat shock protein synthesis, in particular of the 70 kDa heat shock protein (Hsp70). In the current study, we examined the effects of QS on HSV-1 replication in HaCat cells. We also estimated the effects of this drug on the Hsp70, ICP27 and VP16 production and on the activation of NF-kB in HaCat cells that are HSV-1 infected to elucidate the possible mechanisms of the antiviral action of QS.
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