Aim. The aim of thè study was to investigate if VEGF levels reflect thè severity of endometrial cancer and thè clinic relationship between mi-crovasal density (MVD) and concentration of VEGF in tumor. Methods. The study was conducted on 22 pa-tients affected by endometrial cancer who were submitted to total abdominal radicai hysterec-tomy plus bilateral salpingo-ophorectomy. VEGF (pg/mL) and MVD values were measured on histologic specimens of endometrial can¬cer obtained during thè surgical treatment. The means and standard deviations of estimated values were calculated and a statistical com-parison was effected by student t test for not coupled data. Pearson correlation test was used to analyze thè eventual correlation among VEGF and MVD values in overall patients. Results. We have documented that VEGF ex-pression and MVD change according to FIGO stage, lympho-vascular infiltration and lymph node involvement. Pearson correlation test shows a good linear positive correlation in over¬all patients between VEGF and MVD values. Conclusions. Results obtained show a possible use of VEGF as prognostic factor in endome¬trial cancer. Confirmation of these data may permit both to identify high-risk patients, who must be treated with a more aggressive treat¬ment, and to use an angiogenic therapy in en¬dometrial cancer.

Vascular endothelial grow factor (VEGF): can we use it as prognostic factor in endometrial cancer?

BALBI, Giancarlo;
2006

Abstract

Aim. The aim of thè study was to investigate if VEGF levels reflect thè severity of endometrial cancer and thè clinic relationship between mi-crovasal density (MVD) and concentration of VEGF in tumor. Methods. The study was conducted on 22 pa-tients affected by endometrial cancer who were submitted to total abdominal radicai hysterec-tomy plus bilateral salpingo-ophorectomy. VEGF (pg/mL) and MVD values were measured on histologic specimens of endometrial can¬cer obtained during thè surgical treatment. The means and standard deviations of estimated values were calculated and a statistical com-parison was effected by student t test for not coupled data. Pearson correlation test was used to analyze thè eventual correlation among VEGF and MVD values in overall patients. Results. We have documented that VEGF ex-pression and MVD change according to FIGO stage, lympho-vascular infiltration and lymph node involvement. Pearson correlation test shows a good linear positive correlation in over¬all patients between VEGF and MVD values. Conclusions. Results obtained show a possible use of VEGF as prognostic factor in endome¬trial cancer. Confirmation of these data may permit both to identify high-risk patients, who must be treated with a more aggressive treat¬ment, and to use an angiogenic therapy in en¬dometrial cancer.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/227170
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