Inhibition of IKKalpha switches the antiapoptotic effect of estradiol to apoptotic effect in breast cancer cells. Thus estradiol in combination with IKKalpha inhibitors might be used in new trials for the therapy of breast cancers.

Binary switch between adjacent marks in histone H3 directs productive transcription in estrogen-induced breast cancer cells upon cyclical creation of ROS.

Di Donato M;CASTORIA, Gabriella;MIGLIACCIO, Antimo;
2014

Abstract

Inhibition of IKKalpha switches the antiapoptotic effect of estradiol to apoptotic effect in breast cancer cells. Thus estradiol in combination with IKKalpha inhibitors might be used in new trials for the therapy of breast cancers.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/225152
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact