Two new thymidine based polymeric supports, in which the nucleosides have been anchored through the thymine moiety to a β-hydroxy thioether functionalized resin via a Mitsunobu reaction, have been prepared. A simple and efficient solid-phase synthesis of 5′,3′-bis-derivatized thymidine analogues has so been developed, following methodologies well established in peptide and oligonucleotide chemistry and is here proposed for the preparation of a variety of different nucleoside conjugate products. © 2001 The Royal Society of Chemistry.
New nucleoside based solid supports. Synthesis of 5 ',3 '-derivatized thymidine analogues
MESSERE, Anna;
2001
Abstract
Two new thymidine based polymeric supports, in which the nucleosides have been anchored through the thymine moiety to a β-hydroxy thioether functionalized resin via a Mitsunobu reaction, have been prepared. A simple and efficient solid-phase synthesis of 5′,3′-bis-derivatized thymidine analogues has so been developed, following methodologies well established in peptide and oligonucleotide chemistry and is here proposed for the preparation of a variety of different nucleoside conjugate products. © 2001 The Royal Society of Chemistry.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
