A systematic study to evaluate the ability of 5′-DNA-3′ -p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3′-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex.
Synthesis and DNA binding properties of DNA-PNA chimeras
MESSERE, Anna;
2003
Abstract
A systematic study to evaluate the ability of 5′-DNA-3′ -p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3′-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex.File in questo prodotto:
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