Alveolar macrophages (A.M.) are the main resi¬dent phagocytes in the human lung, and play a nayor role in local defence against environmen¬tal agents. Stimulation of these cells by dif-ferent stimula (antigen,LPS etc.) induces the release of a large amount of inflammatory re-sponse mediators. Vim of our work has been study the different be laviour of A.M. from normal subjects and asthma tic patients. In particular, we have evaluated the secretion both of specific cytokines and sicosanoids from resting and activated A.M. Che results show that in vitro the A.M. from asthmatic patients have a high basal secretion 3f immune mediators and it was possible to in¬crease this production by the addition of the specific allergen.
INCREASED GENERATION OF CYTOKINES AND EICOSA_ TOIDS FROM RESTING AND ACTIVATED HOMAN ALVEO¬LAR MACROPHAGES IN PATIENTS WITH ASTHMA.
MAZZARELLA, Gennaro;
1992
Abstract
Alveolar macrophages (A.M.) are the main resi¬dent phagocytes in the human lung, and play a nayor role in local defence against environmen¬tal agents. Stimulation of these cells by dif-ferent stimula (antigen,LPS etc.) induces the release of a large amount of inflammatory re-sponse mediators. Vim of our work has been study the different be laviour of A.M. from normal subjects and asthma tic patients. In particular, we have evaluated the secretion both of specific cytokines and sicosanoids from resting and activated A.M. Che results show that in vitro the A.M. from asthmatic patients have a high basal secretion 3f immune mediators and it was possible to in¬crease this production by the addition of the specific allergen.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
