Objective: The combination of paclitaxel and platinum compounds is considered thè best first-line regimen for advanced ovarian carcinoma. The purpose of this study was to evaluate a paclitaxel and carboplatin combination in pretreated patients who recurred within 24 months after a complete clinical response with thè same regimen used as first-line chemotherapy. Methods: 18 patients were included in this study. Second-line chemotherapy consisted of paclitaxel, 175 mg/m- as a 3-hour infu-sion, and carboplatin AUC 6 every 21 days. Resulti: Among 15 evaluable patients, eight (53%) complete and five (34%) partial responses were observed, while two (13%) patients had stable disease (SD). The response rate was 67% among patients with measurable disease and 52% for evaluable disease. The median progression-free interval after second-line chemotherapy was 8.3 months. The median progression-free interval for patients with measurable disease was 8.6 months and for evaluable disease it was 7.9 months. Seven (46%) of 15 patients bave developed recurrence after second-line chemotherapy with paclitaxel and carboplatin with a median time to recurrence of 9.8 months. Conclusion: Paclitaxel 175 mg/m: and carboplatin AUC 6 as second-line chemotherapy in this sensitive population is effective in terms of response rate and progression-free interval.

Second-line with paclitaxel and carboplatin for recurrent disease following first paclitaxel and platinum compounds in ovarian carcinoma

BALBI, Giancarlo;
2002

Abstract

Objective: The combination of paclitaxel and platinum compounds is considered thè best first-line regimen for advanced ovarian carcinoma. The purpose of this study was to evaluate a paclitaxel and carboplatin combination in pretreated patients who recurred within 24 months after a complete clinical response with thè same regimen used as first-line chemotherapy. Methods: 18 patients were included in this study. Second-line chemotherapy consisted of paclitaxel, 175 mg/m- as a 3-hour infu-sion, and carboplatin AUC 6 every 21 days. Resulti: Among 15 evaluable patients, eight (53%) complete and five (34%) partial responses were observed, while two (13%) patients had stable disease (SD). The response rate was 67% among patients with measurable disease and 52% for evaluable disease. The median progression-free interval after second-line chemotherapy was 8.3 months. The median progression-free interval for patients with measurable disease was 8.6 months and for evaluable disease it was 7.9 months. Seven (46%) of 15 patients bave developed recurrence after second-line chemotherapy with paclitaxel and carboplatin with a median time to recurrence of 9.8 months. Conclusion: Paclitaxel 175 mg/m: and carboplatin AUC 6 as second-line chemotherapy in this sensitive population is effective in terms of response rate and progression-free interval.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11591/221852
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