The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.
Solid-phase synthesis of glyco-oligonucleotide conjugates
MESSERE, Anna;
2001
Abstract
The first examples of direct glycosidation of the 5′-OH end of polypyrimidine oligonucleotides still attached to the CPG solid support are reported. A general re-elongation solid phase procedure has been developed to successfully isolate the target 5′-glycosyl derivatives. A 3′,5′-diglucosylated 16-mer oligonucleotide has also been obtained.File in questo prodotto:
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