1. 1. The effect of cold exposure and of PTU and PTU + T3 administration on the protein content and succinic dehydrogenase activity of three mitochondrial populations obtained from rat liver was examined. Our results indicated the following: 2. 2. Succinic dehydrogenase activity increases mainly in the light mitochondrial fraction of cold-exposed rats. 3. 3. PTU administration of cold-exposed animals does not affect the increment in enzyme activity of the heavy fraction but blocks the increment of the light fraction. 4. 4. PTU + T3 administration restores succinic dehydrogenase activity to the values prevalent in normal cold-exposed rats. 5. 5. These findings suggest that thyroid hormone may stimulate the formation of light mitochondria during cold exposure. © 1986.
Tri-iodothyronine enhances the formation of light mitochondria during cold exposure
LANNI, Antonia;
1986
Abstract
1. 1. The effect of cold exposure and of PTU and PTU + T3 administration on the protein content and succinic dehydrogenase activity of three mitochondrial populations obtained from rat liver was examined. Our results indicated the following: 2. 2. Succinic dehydrogenase activity increases mainly in the light mitochondrial fraction of cold-exposed rats. 3. 3. PTU administration of cold-exposed animals does not affect the increment in enzyme activity of the heavy fraction but blocks the increment of the light fraction. 4. 4. PTU + T3 administration restores succinic dehydrogenase activity to the values prevalent in normal cold-exposed rats. 5. 5. These findings suggest that thyroid hormone may stimulate the formation of light mitochondria during cold exposure. © 1986.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
