Oligonucleotides with a 3' -3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes. Copyright © 2001 Elsevier Science Ltd.
Oligonucleotides containing a lysine residue as 3 '-3 ' junction for alternate strand triple helix formation
MESSERE, Anna;
2001
Abstract
Oligonucleotides with a 3' -3' inversion of polarity site assured by one lysine residue have been synthesized, characterized and used as third strands in alternate strand triple helix formation. UV melting studies and molecular mechanics calculations have been carried out to investigate the stability and the geometry of these new triplexes. Copyright © 2001 Elsevier Science Ltd.File in questo prodotto:
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