Usefulness of IFN-gamma release assays in clinical management of difficult TB cases: Evidence from clinical practice

Bocchino, M.; Matarese, A; Bellofiore, B; Giacomelli, P; Russo, A; Signoriello, Giuseppe; Galati, D; Sanduzzi, A.

doi:1721-727X

Performance of T-SPOT.TB™ (TS-TB) and QuantiFERON TB Gold-In tube (QFT-IT) assays was evaluated for detection of M. tuberculosis (Mtb) infection in patients with suspected extra-pulmonary or smear-negative pulmonary tuberculosis (TB) in a low prevalence country. Twenty-one out of 35 patients were affected by active TB. Mtb culture isolation was achieved in 76% of cases. Tuberculin skin testing (TST), TS-TB, and QFT-IT yielded a positive result in 67%, 95% and 81% of cases, respectively. Agreement of interferon-γ release assays and TST was 70% (κ=0.18 for TS-TB; κ=0.46 for QFT-IT). Increased sensitivity of blood assays (>80%) improved diagnostic evaluation of difficult TB cases. Copyright © by BIOLIFE, s.a.s.

Titolo:	Usefulness of IFN-gamma release assays in clinical management of difficult TB cases: Evidence from clinical practice
Autori:	BOCCHINO M. MATARESE A BELLOFIORE B GIACOMELLI P RUSSO A SIGNORIELLO, Giuseppe GALATI D SANDUZZI A. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2010
Rivista:	EUROPEAN JOURNAL OF INFLAMMATION
Abstract:	Performance of T-SPOT.TB™ (TS-TB) and QuantiFERON TB Gold-In tube (QFT-IT) assays was evaluated for detection of M. tuberculosis (Mtb) infection in patients with suspected extra-pulmonary or smear-negative pulmonary tuberculosis (TB) in a low prevalence country. Twenty-one out of 35 patients were affected by active TB. Mtb culture isolation was achieved in 76% of cases. Tuberculin skin testing (TST), TS-TB, and QFT-IT yielded a positive result in 67%, 95% and 81% of cases, respectively. Agreement of interferon-γ release assays and TST was 70% (κ=0.18 for TS-TB; κ=0.46 for QFT-IT). Increased sensitivity of blood assays (>80%) improved diagnostic evaluation of difficult TB cases. Copyright © by BIOLIFE, s.a.s.
Handle:	http://hdl.handle.net/11591/194745
Appare nelle tipologie:	1.1 Articolo in rivista

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