We screened 685 subjects from Southern Italy for a promoter polymorphism of the UDP-glucuronosyltransferase (UGTA1) gene tightly linked to Gilbert’s syndrome (GS), consisting in the insertion of a TA repeat in the TATA box. The frequency of the polymorphism was 0.387 which is similar to the frequencies reported for other investigated populations of different ethnic backgrounds and is consistent with the antiquity of this polymorphism.
FREQUENCY OF GILBERT'S SYNDROME ASSOCIATED WITH UGTA1 (TA)(7) POLYMORPHISM IN SOUTHERN ITALY
PERROTTA, Silverio;MIRAGLIA DEL GIUDICE, Emanuele
2000
Abstract
We screened 685 subjects from Southern Italy for a promoter polymorphism of the UDP-glucuronosyltransferase (UGTA1) gene tightly linked to Gilbert’s syndrome (GS), consisting in the insertion of a TA repeat in the TATA box. The frequency of the polymorphism was 0.387 which is similar to the frequencies reported for other investigated populations of different ethnic backgrounds and is consistent with the antiquity of this polymorphism.File in questo prodotto:
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